J Periodontol:种植体周围炎和牙周炎一样吗?

2017-04-27 MedSci MedSci原创

本研究旨在通过横断面研究收集接受种植修复患者其健康及种植体周围炎位点的龈沟液来评估其种植体龈沟液(PICF)/龈沟液(GCF)中细胞因子的水平。 研究共纳入了15名无系统性疾病的研究对象,共包括97颗种植体/牙齿(58颗种植体:19颗健康,20颗种植体周围黏膜炎,19颗种植体周围炎;39颗天然牙:19颗健康,12颗牙龈炎,8颗牙周炎),收取PICF/GCF进行免疫检测,实时定量PCR分析。收

本研究旨在通过横断面研究收集接受种植修复患者其健康及种植体周围炎位点的龈沟液来评估其种植体龈沟液(PICF)/龈沟液(GCF)中细胞因子的水平。

研究共纳入了15名无系统性疾病的研究对象,共包括97颗种植体/牙齿(58颗种植体:19颗健康,20颗种植体周围黏膜炎,19颗种植体周围炎;39颗天然牙:19颗健康,12颗牙龈炎,8颗牙周炎),收取PICF/GCF进行免疫检测,实时定量PCR分析。收集完样本后对其进行牙周检查并记录,包括探诊深度,临床附着水平,探诊出血,斑块指数,角化组龈宽度。采用Wilcoxon、Mann-Whitney和置换试验分别对非独立样本、独立样本、混合非独立和混合独立样品进行分析,并对其进行Spearman相关数据分析。

结果发现,健康植体的PICF中IL-1β的水平明显高于健康天然牙GCF中IL-1β的水平(P = 0.003),牙龈炎组GCF中核因子κB可溶性激活因子(sRANKL)的浓度显著高于种植体黏膜炎组(P = 0.004)。种植体周围炎和牙周炎组生物标志物的水平相似(P>0.05)。健康种植组内氏放线菌和口腔链球菌的水平均显著高于健康天然牙齿组(P<0.05)。种植体周围黏膜炎组中间普氏菌和齿垢密螺旋体的水平明显低于牙龈炎组(P<0.05)。牙周炎组口腔普雷沃菌和口腔链球菌的水平显著升高(P<0.05),而种植体周围炎组齿垢密螺旋体的水平则显著升高(P<0.05)

总而言之,在同一个个体中,种植体与天然牙有些相似之处,但是值得注意的是,二者在生物标志物(IL-1β和sRANKL)以及细菌种类上仍存在一些差异,提示着种植体周围/粘膜炎与牙龈/周炎或存在相似的致病机制。

原始出处:

Gürlek Ö, Gümüş P, et al. Biomarkers and Bacteria Around Implants and Natural Teeth in the Same Individuals. J Periodontol. 2017 Apr 25:1-17. doi: 10.1902/jop.2017.160751.

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    2017-12-24 feather89
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    2017-09-08 huangdf
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    2017-04-29 xiaotaiyang1

    学习分享好习惯

    0

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    2017-04-27 医艺依意

    学习了,谢谢分享

    0

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