PLoS Med: 血浆磷脂n-3和n-6多不饱和脂肪酸与心脏代谢指标和妊娠糖尿病的关系

2019-10-19 不详 MedSci原创

尽管饮食指南中建议多食用多不饱和脂肪酸(PUFA)来改善心脏代谢,但是n-3和n-6 PUFA及其与糖尿病风险之间的相互作用仍然存在争议。重要的是,孕妇中的数据很少。本项研究旨在探究妊娠早期至中期妊娠中血浆磷脂n-3和n-6 PUFA与随后的妊娠糖尿病(GDM)风险是否有关。

背景
尽管饮食指南中建议多食用多不饱和脂肪酸(PUFA)来改善心脏代谢,但是n-3和n-6 PUFA及其与糖尿病风险之间的相互作用仍然存在争议。重要的是,孕妇中的数据很少。本项研究旨在探究妊娠早期至中期妊娠中血浆磷脂n-3和n-6 PUFA与随后的妊娠糖尿病(GDM)风险是否有关。

方法和发现
研究人员在美国国家儿童健康与人类发展研究所(NICHD)进行本项研究的人员招募,共收集了2802例数据,其中107例出现GDM,其孕周在(GWs)10-14、15-26、23-31和33-39时测量了血浆血浆n-3和n-6 PUFA的水平。调整协变量后,单个n-3二十碳五烯酸(EPA),二十二碳五烯酸(DPA)和二十二碳六烯酸(DHA)与胰岛素抵抗标记呈负相关关系,而单个n-6二高-γ-亚麻酸(DGLA)与胰岛素抵抗标记呈正相关。在GW 15–26处,总n-3 PUFA和单个n-3 DPA的标准偏差(SD)增加与GDM的风险降低有关;总n-6个PUFA与GDM之间的关联为零,而与单个n-6 PUFA的关联则是差异。GW 10–14处的γ-亚麻酸(GLA)和GW 10–14和15–26处的DGLA与GDM的危险性高1.40至1.95倍相关,而二十二碳六烯酸(DTA)在GW 15–26与GDM风险降低45%(0.55; 95%CI 0.37–0.83)相关。n-3 PUFA高(≥中位数)和n-6 PUFA低(<中位数)的女性与n-3低的女性相比,其GDM风险降低了64%(95%CI 0.14–0.95;P值= 0.039)。

结论:
本项研究表明,主要内源性代谢的血浆磷脂n-6 PUFA(包括GLA,DGLA和DTA)在GDM的早期至中期妊娠中可能发挥作用。而饮食中的n-3 EPA和DHA和n-6 LA则没有效果,但是也不能排除EPA和DHA对葡萄糖-胰岛素体内稳态的潜在益处。

原始出处:

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    2019-10-20 misszhang

    谢谢MedSci提供最新的资讯

    0