PLoS One: 高敏肌钙蛋白升高,伴有风湿性心脏病的AIS患者预后不良

2016-05-24 MedSci MedSci原创

背景:相当比例的急性缺血性卒中(AIS)患者高敏肌钙蛋白T水平升高(hs-cTnT),并能够预测不良预后和死亡率。hs-cTnT水平升高是否也可以预测出血转化(HT)或风湿性心脏病(RHD)的AIS患者的预后仍不清楚。方法:中国的研究者从成都卒中登记记录中,获取2011年10月到2014年2月入住华西医院的伴有RHD的AIS患者,这些患者在卒中开始1个月后入院。比较高hs-cTnT水平(≥14ng

背景:相当比例的急性缺血性卒中(AIS)患者高敏肌钙蛋白T水平升高(hs-cTnT),并能够预测不良预后和死亡率。hs-cTnT水平升高是否也可以预测出血转化(HT)或风湿性心脏病(RHD)的AIS患者的预后仍不清楚。

方法:中国的研究者从成都卒中登记记录中,获取2011年10月到2014年2月入住华西医院的伴有RHD的AIS患者,这些患者在卒中开始1个月后入院。比较高hs-cTnT水平(≥14ng/L)和正常hs-cTnT水平(14ng/L)。患者的临床和人口统计学特征,HT及功能预后和卒中再发情况。

结果:
最后纳入了84例患者(31为男性;平均年龄61.6±12.2岁),其中血清hs-cTnT升高者占58.3%水平。肾损害与hs-cTnT水平升高独立相关(OR 4.184,95% CI 1.17~15.01,P = 0.028),hs-cTnT水平升高的患者HT的风险,3个月的死亡率和3个月的残疾/死亡率明显增高(P均≤0.029)。校正年龄、性别、高血压、肾功能损害,入院NIHSS后,与正常hs-cTnT水平患者相比,hs-cTnT水平升高的患者HT风险增高4倍,3个月的死亡风险增高5.5倍

结论:hs-cTnT水平升高与伴有RHD 的AIS患者HT和3个月的死亡率独立相关。这些结果需要较大样本量的研究来验证。

原始出处:

Liu J, Wang D, et al. Association of Elevated High Sensitivity Cardiac Troponin T(hs-cTnT) Levels with Hemorrhagic Transformation and 3-Month Mortality in Acute Ischemic Stroke Patients with Rheumatic Heart Disease in China. PLoS One. 2016 Feb 5.

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    2021-03-04 ms5233340938792882

    学习咯

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    2017-02-05 zsyan
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    2017-02-23 膀胱癌
  5. [GetPortalCommentsPageByObjectIdResponse(id=945575, encodeId=5c2f9455e512, content=学习咯, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/AFEE88F419F5C2EE00A4D2529684DE09/100, createdBy=94611950576, createdName=ms5233340938792882, createdTime=Thu Mar 04 23:18:53 CST 2021, time=2021-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1691877, encodeId=c40416918e775, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f4729287700, createdName=bnurmamat, createdTime=Wed Apr 05 12:29:00 CST 2017, time=2017-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779628, encodeId=63ef1e7962851, content=<a href='/topic/show?id=0cff2190ee' target=_blank style='color:#2F92EE;'>#AIS患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2190, encryptionId=0cff2190ee, topicName=AIS患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dab8203, createdName=zsyan, createdTime=Sun Feb 05 19:29:00 CST 2017, time=2017-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634932, encodeId=452e1634932af, content=<a href='/topic/show?id=f8072189cf' target=_blank style='color:#2F92EE;'>#AIS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2189, encryptionId=f8072189cf, topicName=AIS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ef022348744, createdName=膀胱癌, createdTime=Thu Feb 23 00:29:00 CST 2017, time=2017-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789806, encodeId=ed621e898067d, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Sun Jan 08 16:29:00 CST 2017, time=2017-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341050, encodeId=d2ae1341050ce, content=<a href='/topic/show?id=ae7b100829f2' target=_blank style='color:#2F92EE;'>#风湿性心脏病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100829, encryptionId=ae7b100829f2, topicName=风湿性心脏病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fc52500170, createdName=12498cbcm00(暂无昵称), createdTime=Thu May 26 11:29:00 CST 2016, time=2016-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488326, encodeId=257114883267d, content=<a href='/topic/show?id=b34f1001e187' target=_blank style='color:#2F92EE;'>#预后不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100171, encryptionId=b34f1001e187, topicName=预后不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b86b8414062, createdName=caoliehu, createdTime=Thu May 26 11:29:00 CST 2016, time=2016-05-26, status=1, ipAttribution=)]
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