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PloS One：CD13 表达在治疗非小细胞肺癌中的潜在作用

2017-06-19 许奕晗 MedSci原创

CD13Non-smallCelllungCancerEndothelialcells
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我们都知道CD13是也叫氨肽酶N（Aminopeptidase N）是一种锌结合蛋白酶，它对肿瘤血管生成可以起到促进作用。由于CD13 可以作为分子靶向治疗的抗原，用于tTF-NGR诱导的肿瘤血管梗死的治疗，研究人员也在非小细胞肺癌（NSCLC）模型小鼠中测试了CD13 靶向融合蛋白tTF-NGR的治疗效果。

我们都知道CD13是也叫氨肽酶N（Aminopeptidase N）是一种锌结合蛋白酶，它对肿瘤血管生成可以起到促进作用。由于CD13 可以作为分子靶向治疗的抗原，用于tTF-NGR诱导的肿瘤血管梗死的治疗，研究人员也在非小细胞肺癌（NSCLC）模型小鼠中测试了CD13 靶向融合蛋白tTF-NGR的治疗效果。

研究人员首先在270名非小细胞肺癌患者中运用免疫组化的方法测量了CD13和CD31 的表达情况，使用单变量和多变量分析表达谱计算其与临床和预后的相关性。同时在携带有A548肺癌异种移植物的小鼠中检测了CD13靶向融合蛋白tTF-NGR的治疗效果。

结果显示：在15%的患者样本中发现了肿瘤内皮和血管相关细胞中CD13表达增加，虽然在本项试验中没有观察到CD13对于患者预后有显着影响，但是单变量与多变量模型分析都证明了CD13的表达增加对III期和pN2+NSCLC患者总体生存率有负相关作用。在小鼠试验中，CD13靶向融合蛋白tTF-NGR也显着降低了小鼠体内肿瘤的生长。

本项研究的结果为CD13靶向融合蛋白tTF-NGR抗肿瘤治疗提供了依据，以CD13位靶向的药物治疗在将来可能有很大的应用前景。

原始出处：


Lars Henning Schmidt.et al.Potential therapeutic impact of CD13 expression in non-small cell lung cancer.PLoS One.2017.

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    2018-05-03 119337457

    #Plos one#

    0

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    2018-05-15 docwu2019

    #非小细胞#

    0

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    2018-04-13 hyf028

    #CD13#

    0

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    2017-06-20 xuyihan

    学习了

    0

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    2017-06-20 执迷不悔

    学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1789985, encodeId=7cdd1e8998591, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Thu May 03 09:36:00 CST 2018, time=2018-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2059619, encodeId=4ccd2059619e8, content=<a href='/topic/show?id=2cc599381bd' target=_blank style='color:#2F92EE;'>#非小细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99381, encryptionId=2cc599381bd, topicName=非小细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Tue May 15 05:36:00 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1928007, encodeId=a4f1192800e2f, content=<a href='/topic/show?id=a6b54263ae' target=_blank style='color:#2F92EE;'>#CD13#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4263, encryptionId=a6b54263ae, topicName=CD13)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7d40148, createdName=hyf028, createdTime=Fri Apr 13 22:36:00 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212998, encodeId=5242212998c0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbkwiamQRUZ02EtNQ6eQflk4CHafHibKTV9ju5ia6AkEvQuZagYnTGsFTuibpHDwZUicuFmVBsIZ0qbJg/0, createdBy=bc812071404, createdName=xuyihan, createdTime=Tue Jun 20 07:08:09 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212899, encodeId=6216212899f6, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/y6Sk2KiaDibWSs0icexcRzKWXKao9dILdyaB6olvWApA1uiaapa4T9XMiaU7hTZA04uj2iavabfdCT5iaO6AYue5qSJ7MzXaAVSqh6j/0, createdBy=08e01983553, createdName=执迷不悔, createdTime=Tue Jun 20 00:04:14 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212688, encodeId=0a2a2126882a, content=学习了。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo51eheDrP8dFkRicVB5LyaVk2Nc1S87J8nCBgASWQ4rrorsyzzr0UzN8N5bibeqGofE7ZtdT6YNZHEQ/0, createdBy=79351625688, createdName=1dd7a091m35(暂无匿称), createdTime=Mon Jun 19 09:50:21 CST 2017, time=2017-06-19, status=1, ipAttribution=)]
    2017-06-19 1dd7a091m35(暂无匿称)

    学习了。。。。

    0