Lancet Neurol:苍白球脑深部电刺激对重度抽动秽语综合症的影响

2017-06-21 zhangfan MedSci原创

3个月的苍白球脑深部电刺激对重度抽动秽语综合症的症状缓解无显著影响,未来的研究方向将集中于长期电刺激研究、治疗方案变化以及精确的患者分层

模型研究表明脑深部电刺激(DBS)有望治疗重度抽动秽语综合症,小规模的临床试验测试了DBS对苍白球(AGPI)前后路的刺激作用。近日研究人员考察了苍白球脑深部电刺激对重度抽动秽语综合症的影响。

研究招募了成年的,严重且药物难治性抽动秽语综合征患者接受双侧电极植入手术,3个月后患者随机接受电刺激或假性刺激对照,之后所有患者接受6个月的电刺激治疗。研究的主要终点是3个月时组间耶鲁全脑抽动评价分数的差异(YGTSS),研究同时考察电极植入以及苍白球脑深部电刺激的安全性。

研究招募了17名患者,其中16人完成了双盲对照(7人为刺激组,9人为对照组)。研究发现,组间3个月的YGTSS分数变化无显著差异(刺激组基线平均YGTSS分数68.5,3个月后为62.5,平均变化1.1%;对照组基线分数73,终点分数79,平均变化0%),13名患者发生了15起严重不良事件,其中4人发生了植入感染,其他的不良事件包括电极错位、抑郁以及抽搐和焦虑严重程度增加。

研究认为,3个月的苍白球脑深部电刺激对重度抽动秽语综合症的症状缓解无显著影响,未来的研究方向将集中于长期电刺激研究、治疗方案变化以及精确的患者分层。

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    2018-05-10 lsndxfj
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    2017-10-06 howi
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    2017-09-20 yinhl1978
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    2017-06-23 0348

    真是好消息

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1942235, encodeId=a4ed194223587, content=<a href='/topic/show?id=9a9d869e164' target=_blank style='color:#2F92EE;'>#苍白球#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86971, encryptionId=9a9d869e164, topicName=苍白球)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Thu May 10 09:59:00 CST 2018, time=2018-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1829030, encodeId=fc9d182903046, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Fri Oct 06 14:59:00 CST 2017, time=2017-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999995, encodeId=fdef199999554, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Sep 20 06:59:00 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214154, encodeId=1ccc214154e9, content=真是好消息, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/04/04/355c07748bd28246a802dedc6fdf7421.jpg, createdBy=4cfd1732073, createdName=0348, createdTime=Fri Jun 23 06:20:25 CST 2017, time=2017-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394000, encodeId=068a13940003f, content=<a href='/topic/show?id=a054e00031c' target=_blank style='color:#2F92EE;'>#电刺激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70003, encryptionId=a054e00031c, topicName=电刺激)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqTLTjicBiccpdUyHMGZV43nOBI6QIQqxVcy2EzXz67E390Q5j0R7QWjym391HxsyiaYt7NzbrcojRDw/132, createdBy=64462500151, createdName=ms705947299214030, createdTime=Fri Jun 23 04:59:00 CST 2017, time=2017-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213524, encodeId=54582135246b, content=真的管用吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Wed Jun 21 15:00:36 CST 2017, time=2017-06-21, status=1, ipAttribution=)]
    2017-06-21 楠博One

    真的管用吗

    0

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