Heart:慢性炎症能明显增加心血管疾病发生风险!

2018-01-07 MedSci MedSci原创

本研究的目的旨在评估慢性炎症性疾病(类风湿性关节炎、系统性红斑狼疮或慢性免疫介导的炎症等)与冠心病、卒中和心血管疾病的发生率与死亡率的关系。本研究纳入了991546名年龄在35-85岁无心血管疾病史的个体,并对每种结局通过2种模型进行Cox回归分析,模型1是在经性别、年龄和心血管危险因素进行调整后分析,模型2是在模型1的基础上进一步按药物使用进行调整后分析。最终分析结果显示,心血管疾病风险在全身结

本研究的目的旨在评估慢性炎症性疾病(类风湿性关节炎、系统性红斑狼疮或慢性免疫介导的炎症等)与冠心病、卒中和心血管疾病的发生率与死亡率的关系。

本研究纳入了991546名年龄在35-85岁无心血管疾病史的个体,并对每种结局通过2种模型进行Cox回归分析,模型1是在经性别、年龄和心血管危险因素进行调整后分析,模型2是在模型1的基础上进一步按药物使用进行调整后分析。最终分析结果显示,心血管疾病风险在全身结缔组织病患者中明显更高(模型1:HR=1.38 (95% CI 1.21-1.57);模型2:HR=1.31 (95% CI 1.15-1.49)),在类风湿性关节炎患者中也明显更高(HR=1.43 (95% CI 1.26-1.62) ;HR=1.31 (95% CI 1.15-1.49)),在炎症性肠病患者中同样更高(HR=1.18 (95% CI 1.06-1.32) ;HR=1.12 (95% CI 1.01-1.25)),并且抗炎症治疗能明显降低这种差异。

研究结果显示,全身结缔组织病和类风湿性关节炎能明显增加个体心血管疾病的发生风险。

原始出处:


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    2018-01-09 zhaojie88
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    2018-01-09 slcumt
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    2018-01-08 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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    2018-01-07 王秀

    学习了.涨知识了!

    0

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    2018-01-07 天地飞扬

    学习了.谢谢分享!

    0

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