JAHA:保留射血分数的无症状重度主动脉瓣狭窄患者的超声心动图结果

2018-04-15 xiangting MedSci原创

无症状重度主动脉瓣狭窄患者接受平板负荷超声心动图检查时,LV-GLS和ZVa提供额外的预后价值。

这项研究在保留左心室射血分数的无症状重度主动脉瓣狭窄患者中,评估了静息瓣膜动脉阻抗(Zva)和左室整体纵向应变(LV-GLS)对平板负荷超声心动图的增量预后价值。

共研究了504名此类患者(66±12岁,78%男性,32%有冠心病在2001年至2012年间接受平板负荷超声心动图检查)。记录了临床和运动变量(%年龄-性别预测的代谢当量[%AGP-METS])。从基线静息超声心动图得到静息Zva([收缩动脉压+平均主动脉瓣梯度]/[LV -每搏量指数])和LV-GLS(使用速度向量成像,西门子)。主要终点是死亡,在平板负荷超声心动图检查中没有重大心脏不良事件。主动脉瓣区面积、Zva和LV-GLS分别为0.46±0.1cm2/m2,4.5±0.9mmHg/ml每平方米和-16±4%。只有50%达到>100%AGP-METs。64%接受了主动脉瓣置换术。8.9±3.6年内(主动脉瓣置换术后30天内死亡2例)死亡164例(33%)。在多变量Cox生存分析中,较高的胸外科医师协会评分(风险比或HR 1.06),较低的AGP-METS(HR 1.16),较高的Zva(HR 1.25)和较低的LV-GLS(HR 1.12)与较高的长期死亡率相关,而主动脉瓣置换术(HR 0.45)与生存率改善相关(P均 <0.01)。将ZVa和LV-GLS顺序加入临床模型(胸外科医师协会评分和%AGP-METs),使c统计值从0.65增加到0.69和0.75, P均<0.001。主动脉瓣置换患者亚组的结果相似。

无症状重度主动脉瓣狭窄患者接受平板负荷超声心动图检查时,LV-GLS和ZVa提供额外的预后价值。

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createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Apr 15 16:31:10 CST 2018, time=2018-04-15, status=1, ipAttribution=)]
    2018-04-17 zhaohui6731
  5. 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  6. 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  7. 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  8. 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    2018-04-15 有备才能无患

    这项研究在保留左心室射血分数的无症状重度主动脉瓣狭窄患者中.评估了静息瓣膜动脉阻抗(Zva)和左室整体纵向应变(LV-GLS)对平板负荷超声心动图的增量预后价值.

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  9. 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    2018-04-15 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

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