J Hypertens:阻塞性睡眠呼吸暂停对急性缺血性卒中患者心脏器官损害的影响!

2018-03-23 xing.T MedSci原创

由此可见,与不伴有OSA的患者相比,伴有OSA的急性卒中患者左心室质量较大,左心房扩大。这项研究证实了卒中患者中OSA较高的患病率,这也表明OSA与心脏靶器官损伤之间存在关联。研究人员发现伴有OSA的急性卒中患者的结构性LV异常提示OSA作为决定脑血管和心脏损伤促进因素的潜在作用,即使与血压升高病史之间没有明确的关系。

阻塞性睡眠呼吸暂停(OSA)和心脏器官损伤在急性缺血性卒中患者中发挥着关键作用。近日,高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章,研究人员的目标是探索急性卒中患者OSA与心脏器官损伤之间的关系。

该研究招募了130例连续就诊的急性缺血性卒中患者。患者接受了完全多通道24小时多导睡眠监测以评估OSA,以及进行超声心动图检查以评估左心室(LV)质量指数(LV质量/BSA,LV质量/身高2.7)、室间隔(IVS)和后壁(LVPW)厚度、左室射血分数和左心房扩大。从患者的病史中获取关于高血压发生以及卒中前治疗的信息。

在61.9%(70)的急性卒中患者,主要为男性(67.1%),患有OSA(AHI>10)。与没有OSA的患者相比,急性卒中和OSA患者的LV质量指数、IVS和LVPW厚度显着增加以及左心房显著扩大(P <0.05)。伴有和不伴有OSA的卒中患者之间左室射血分数没有显著差异,并处于正常范围内。在心脏改变、OSA发生和高血压病史之间没有发现相关性。

由此可见,与不伴有OSA的患者相比,伴有OSA的急性卒中患者左心室质量较大,左心房扩大。这项研究证实了卒中患者中OSA较高的患病率,这也表明OSA与心脏靶器官损伤之间存在关联。研究人员发现伴有OSA的急性卒中患者的结构性LV异常提示OSA作为决定脑血管和心脏损伤促进因素的潜在作用,即使与血压升高病史之间没有明确的关系。

原始出处:

Mattaliano, Paola,et al.Impact of obstructive sleep apnea on cardiac organ damage in patients with acute ischemic stroke.Journal of Hypertension. 2018. https://journals.lww.com/jhypertension/Abstract/publishahead/Impact_of_obstructive_sleep_apnea_on_cardiac_organ.97503.aspx

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  5. 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  6. 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  7. 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    2018-04-18 成长中

    整体观

    0

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    2018-08-26 feather89

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