Autophagy:视网膜母细胞瘤化疗增效或有新靶标

2014-06-23 驻地记者颜秋雨通讯员 王建新 江冰 中国医学论坛报

中南大学湘雅二医院眼科在视网膜母细胞瘤(RB)细胞自噬及凋亡的研究方面,发现可提高化疗效果的靶标,为该病及眼内恶性肿瘤治疗提供了新的思路。研究论文发表于《自噬》[Autophagy2014;10(4):42]杂志。 该研究以miR-34a是否参与调节RB化疗药物敏感性为目的,采用先进的试验技术及研究手段,最终证实,高迁移率族蛋白(HMG)B1是miR-34a在RB细胞内的作用目标之一,miR-3

中南大学湘雅二医院眼科在视网膜母细胞瘤(RB)细胞自噬及凋亡的研究方面,发现可提高化疗效果的靶标,为该病及眼内恶性肿瘤治疗提供了新的思路。研究论文发表于《自噬》[Autophagy2014;10(4):42]杂志。

该研究以miR-34a是否参与调节RB化疗药物敏感性为目的,采用先进的试验技术及研究手段,最终证实,高迁移率族蛋白(HMG)B1是miR-34a在RB细胞内的作用目标之一,miR-34a可以降低HMGB1的mRNA水平以促进RB细胞的凋亡并抑制自噬,同时通过增加细胞DNA的损伤来提高化疗药物对RB细胞的治疗效果。

这一研究结论可望揭示miR-34a在细胞自噬作用中的新机制,为临床提高治疗RB疗效以及其他眼部恶性肿瘤,提供了新的思路及方法。

原始出处

Klionsky DJ1, Eskelinen EL2.The vacuole versus the lysosome: when size matters.Autophagy. 2014 Feb;

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    2014-07-31 sweetai

    中国人的研究,不错

    0

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    2014-06-25 zutt
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    2014-06-25 zhaojie88
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