Clin Nutr:胃肠道肿瘤患者术后肠内外营养比较

2016-08-06 Mechront 译 MedSci原创

背景:为了提高临床疗效,肠外营养(PN)、标准肠内营养(SEN)和免疫增强肠内营养(IEN)在胃肠道肿瘤患者手术中得到广泛应用,但术后营养支持的优化管理仍不明确。方法:我们系统地检索了PubMed、EMBASE、CNKI等数据库中比较标准EN与PN或IEN对胃肠道肿瘤患者影响的研究。结果:在我们的荟萃分析中包含30个随机对照试验,涉及3854例患者。数据显示,术后SEN可显著降低术后感染率绝对风险

背景:为了提高临床疗效,肠外营养(PN)、标准肠内营养(SEN)和免疫增强肠内营养(IEN)在胃肠道肿瘤患者手术中得到广泛应用,但术后营养支持的优化管理仍不明确。

方法:我们系统地检索了PubMed、EMBASE、CNKI等数据库中比较标准EN与PN或IEN对胃肠道肿瘤患者影响的研究。

结果:在我们的荟萃分析中包含30个随机对照试验,涉及3854例患者。数据显示,术后SEN可显著降低术后感染率绝对风险(P < 0.00001)和非感染性并发症的绝对风险(P = 0.0003),且对住院时间长短有积极的影响(P < 0.00001)。

此外,免疫刺激增强的肠内营养被证实是更好的选择,在感染(P < 0.00001)和非感染性并发症方面(P = 0.04)具有显著的组间差异;IEN还能显著缩短住院时长(P < 0.00001)。

结论:消化道肿瘤患者术后早期使用肠内营养可显著减少术后并发症、缩短住院时间,IEN或许是最佳选择;不过对于肠内营养严重不耐受的少数患者,还是应该选择肠外营养。

原始出处:


Yan X.et al.Optimal postoperative nutrition support for patients with gastrointestinal malignancy: A systematic review and meta-analysis.Clin Nutr. 2016 Jul 2. pii: S0261-5614(16)30143-1. doi: 10.1016/j.clnu.2016.06.011

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    2016-09-23 1e10c84am36(暂无匿称)

    深度好文,值得学习

    0

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    2016-09-16 1e10c84am36(暂无匿称)

    不错哦,会学到很多

    0

  4. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Aug 10 23:18:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97222, encodeId=faa19e222c9, content=科学应用术后肠内外营养。, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Aug 10 07:35:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97105, encodeId=a68e9e10542, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 09 18:35:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
    2016-09-16 1e10c84am36(暂无匿称)

    不错哦,会学到很多

    0

  5. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Aug 10 23:18:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97222, encodeId=faa19e222c9, content=科学应用术后肠内外营养。, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Aug 10 07:35:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97105, encodeId=a68e9e10542, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 09 18:35:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
    2016-09-05 李东泽

    很好,不错,以后会多学习

    0

  6. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Aug 10 23:18:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97222, encodeId=faa19e222c9, content=科学应用术后肠内外营养。, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Aug 10 07:35:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97105, encodeId=a68e9e10542, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2016-08-26 ylzr123

    深度好文,赞一个!!!

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 16 09:15:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=111594, encodeId=996811159440, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Sep 05 16:46:00 CST 2016, time=2016-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=104182, encodeId=aadc10418253, content=深度好文,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Aug 10 23:18:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97222, encodeId=faa19e222c9, content=科学应用术后肠内外营养。, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Aug 10 07:35:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97105, encodeId=a68e9e10542, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 09 18:35:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
    2016-08-11 忠诚向上

    好好学习

    0

  8. 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likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Aug 26 09:04:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97406, encodeId=83ef9e406e1, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Thu Aug 11 07:30:00 CST 2016, time=2016-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97378, encodeId=58459e378f3, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Aug 10 23:18:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97222, encodeId=faa19e222c9, content=科学应用术后肠内外营养。, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Aug 10 07:35:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97105, encodeId=a68e9e10542, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 09 18:35:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
    2016-08-10 忠诚向上

    好好学习

    0

  9. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Aug 10 23:18:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97222, encodeId=faa19e222c9, content=科学应用术后肠内外营养。, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Aug 10 07:35:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97105, encodeId=a68e9e10542, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 09 18:35:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
    2016-08-10 jyzxjiangqin

    科学应用术后肠内外营养。

    0

  10. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Aug 10 23:18:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97222, encodeId=faa19e222c9, content=科学应用术后肠内外营养。, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Aug 10 07:35:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97105, encodeId=a68e9e10542, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 09 18:35:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
    2016-08-09 doctorJiangchao

    继续学习

    0

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ECC 2015:阿司匹林抗癌效果突出,肿瘤患者生存时长可翻倍

根据2015年欧洲癌症大会的观点,阿司匹林可使胃肠道癌症患者的生存几率翻倍。 荷兰莱顿大学医学中心Martine Frouws博士领导的研究团队指出,他们有越来越多的证据表明阿司匹林可用于预防和治疗癌症,且效果卓著。 上个月,Medical News Today报道了一项研究,表明阿司匹林可以降低民众患结直肠癌的风险。而一项最近的研究指出,阿司匹林可能有助于提高乳腺癌、皮肤癌和肠道癌症患者的治疗效

ONF:针灸能改善胃肠道肿瘤患者食欲,降低体重下降速度

研究目的:我们实验的目的是:探究使用中医针灸疗法作为现有胃肠道癌症患者治疗措施的互补干预疗法的可行性,并且评估其在降低胃肠道肿瘤患者体重减轻速度的有效性。研究方式:一个实验组,探究其使用中医针灸治疗干预前后的效果及其可行性。环境:实验在佛罗里达州一个肿瘤门诊和一个肿瘤活动中心进行。样本:7位胃肠道肿瘤患者。实验方式:我们在8周的时间内为患者提供了8节针灸课教育,最后使用视觉模拟评分量表(VAS)&

ASCO年度报告:2011临床肿瘤学重大进展之胃肠道肿瘤

  前瞻性、开放、多中心、随机Ⅲ期研究(SSGXⅧ)比较的是12个月与36个月伊马替尼辅助治疗可手术的、高复发风险胃肠间质瘤(GIST)的疗效和安全性,共有400例Kit阳性GIST患者入组。   中位随访54个月的最终结果显示,与12个月辅助治疗组相比,术后36个月伊马替尼治疗组5年无复发生存(RFS)率(66%对48%,P<0.0001)和5年OS率(92%对82%,P=0.019)均有显著

SG-GICC 2012:胃肠道肿瘤临床困境的科学思辨

       St.Gallen EORTC胃肠道肿瘤大会于3月22~24日在瑞士圣加仑州举行。作为24日共识会的热身和铺垫,3月22-23日,为期两天的专场讨论会为与会者呈现的是对一个个具体临床困境或问题的科学思辨。        ■食管癌       &

沈琳:PET/CT在胃肠道肿瘤诊断与治疗中的应用

     沈琳教授   10月7~9日,由北京大学临床肿瘤学院主办的燕京肿瘤临床与PET/CT应用会议在北京召开。   会上,北京肿瘤医院的沈琳教授报告了PET/CT在胃肠道肿瘤诊断与治疗中的应用。   关于术前分期   沈教授指出,对于胃癌及肠癌,不推荐在术前进行TNM分期时常规使用PET/CT,而结肠癌肝转移患者术前应行PET/CT检查,以避免不必要的手术。   关于术后复发