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Drug Safety：如何对患有痴呆症，但未诊断为精神病的患者进行抗精神病药物治疗？

2017-08-29 MedSci MedSci原创

痴呆症精神病
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近日，国际杂志 《Drug Safety》上在线发表关于在国家指导和药物安全性警戒背景下如何对患有痴呆症，但未诊断为精神病的患者进行抗精神病药物治疗的一项英国通用实践纵向研究结果。

近日，国际杂志 《Drug Safety》上在线发表关于在国家指导和药物安全性警戒背景下如何对患有痴呆症，但未诊断为精神病的患者进行抗精神病药物治疗的一项英国通用实践纵向研究结果。 对那些被诊断为痴呆症的老年人来说，对给予不适当的抗精神病药处方的干预政策措施是很常见的。在英国，医药保健产品监管机构在2004年，2009年和2012年发布了警告，2006年国家研究院发布了国家健康与护理卓越指导。因此评估这种干预措施的影响很重要。 研究人员定期收集分析初级保健数据，这些数据来源于临床实践研究数据链中参加689个一般实践的111,346名受试者。描述针对65岁以上未经伴随的精神病诊断为痴呆症患者的抗精神病药物处方，从2001年到2014年的时间变化，研究使用中断时间序列和和前后设计分析。采用Logistic回归方法量化患者的影响和实践水平变量对处方流行率的影响。 第一代抗精神病药物的处方从2001年的8.9％降至2014年的1.4％（校正实践中年龄，性别和的聚类的患病率比2014/2001（0.14，95％ cl 0.12-0.16），而第二代抗精神病药物几乎没有变化（1.01，置信区间为0

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    2017-12-08 爆笑小医

    #Drug#

    0

  2. 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    2018-06-21 quxin068

    #safety#

    0

  3. 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likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Aug 30 00:06:24 CST 2017, time=2017-08-30, status=1, ipAttribution=)]
    2018-01-25 Boyinsh

    #痴呆症#

    0

  4. 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    2017-08-31 12498768m16(暂无昵称)

    #抗精神病药#

    0

  5. 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likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Aug 30 00:06:24 CST 2017, time=2017-08-30, status=1, ipAttribution=)]
    2017-08-30 130****4638

    学习了谢谢分享

    0

  6. 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likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Aug 30 00:06:24 CST 2017, time=2017-08-30, status=1, ipAttribution=)]
    2017-08-30 meiliwuxian

    厉害

    0

  7. 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likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Aug 30 00:06:24 CST 2017, time=2017-08-30, status=1, ipAttribution=)]
    2017-08-30 baihao215

    药物管理.学习了

    0

  8. 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likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Aug 30 00:06:24 CST 2017, time=2017-08-30, status=1, ipAttribution=)]
    2017-08-30 changjiu

    学习一下谢谢

    0

  9. 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likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Aug 30 00:06:24 CST 2017, time=2017-08-30, status=1, ipAttribution=)]
    2017-08-30 cherry bomb

    学习了谢谢分享!

    0

  10. 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    2017-08-30 飛歌

    厉害了我的哥

    0

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全球超过三分之一的痴呆症病例可通过风险影响因素的生活方式干预得到预防。这些可改变的风险因素涉及多个人生阶段而不仅仅是老年。

JCO：雄激素剥夺治疗(ADT)对于前列腺癌老年患者来说，没有增加AD风险，对痴呆症也没有任何有意义的风险！

近日，在医学权威杂志JAMA上面发表了一篇研究文章，研究人员在调整其他癌症治疗后，探讨雄激素剥夺治疗(ADT)对于前列腺癌患者来说患阿尔兹海默症的相对风险。