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Cell Host Microbe：鸭子出现变异禽流感病毒亚型

2018-10-09 唐凤 中国科学报

鸭子变异禽流感
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为了应对禽流感流行，我国在2017年9月推出了一种新型鸡用疫苗。近日，中国农科院研究人员发现，这种疫苗效果显著，但值得注意的是，研究人员在未免疫的鸭子中发现了H7N9和H7N2的两种新基因变异亚型。相关论文日前发表在《细胞—宿主与微生物》上。

为了应对禽流感流行，我国在2017年9月推出了一种新型鸡用疫苗。近日，中国农科院研究人员发现，这种疫苗效果显著，但值得注意的是，研究人员在未免疫的鸭子中发现了H7N9和H7N2的两种新基因变异亚型。相关论文日前发表在《细胞—宿主与微生物》上。

该论文主要作者、中国农科院哈尔滨兽医研究所动物病毒学家陈化兰指出，出乎意料的是，这种新的高致病性亚型在鸭子中产生，并能很好地适应，而原来的高致病性H7N9在鸭子体内复制能力非常有限。

陈化兰团队在接种疫苗8个月前和5个月后分别收集了37928只鸡和15956只鸭子的基因样本，结果在疫苗注射前分离出304种H7N9病毒，之后仅分离出17种H7N9病毒和1种H7N2病毒。

研究人员表示，数据显示，鸡的疫苗接种成功地阻止了H7N9病毒的传播。但禽流感病毒能在宿主细胞中复制，并经常发生突变和重组。当该团队仔细观察鸭子致病菌株的基因类型时，发现H7N9和H7N2病毒从其他鸭类流感病毒中获取了某些基因片段，提高了它们感染鸭子的能力。

据统计，我国消费者每年大约要吃掉30亿只鸭子。为了防止进一步的人类感染，研究人员认为应该尽快在鸭子中消灭这种病毒。陈化兰表示，幸运的是，研究表明目前的疫苗对鸭子也将有效，所以建议立即为鸭子注射H7疫苗。

原始出处：

Jian zhong Shi, Guo hua Deng, Shu jie Ma, et.al. Rapid Evolution of H7N9 Highly Pathogenic Viruses that Emerged in China in 2017. Cell Host & Microbe Available online 27 September 2018

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    2018-10-18 维他命

    #CEL#

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    2019-01-26 zhaozhouchifen

    #Cell#

    0

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    2019-07-29 yhj-time

    #禽流感病#

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    2019-08-15 xjy02

    #Micro#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1961179, encodeId=b34a19611e94d, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Thu Oct 18 06:58:00 CST 2018, time=2018-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870908, encodeId=a35a18e090857, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Jan 26 17:58:00 CST 2019, time=2019-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1802045, encodeId=5403180204516, content=<a href='/topic/show?id=52b2e47257e' target=_blank style='color:#2F92EE;'>#禽流感病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74725, encryptionId=52b2e47257e, topicName=禽流感病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=37d0457, createdName=yhj-time, createdTime=Mon Jul 29 11:58:00 CST 2019, time=2019-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084448, encodeId=077420844482f, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Thu Aug 15 10:58:00 CST 2019, time=2019-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857707, encodeId=3580185e707b2, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Mon Jan 07 18:58:00 CST 2019, time=2019-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342522, encodeId=95fb1342522bd, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Thu Oct 11 09:58:00 CST 2018, time=2018-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573730, encodeId=cb8815e373078, content=<a href='/topic/show?id=8ffbe472637' target=_blank style='color:#2F92EE;'>#禽流感病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74726, encryptionId=8ffbe472637, topicName=禽流感病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=847a15925078, createdName=venlin, createdTime=Thu Oct 11 09:58:00 CST 2018, time=2018-10-11, status=1, ipAttribution=)]
    2019-01-07 jiafufeng@yaho

    #CRO#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1961179, encodeId=b34a19611e94d, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Thu Oct 18 06:58:00 CST 2018, time=2018-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870908, encodeId=a35a18e090857, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Jan 26 17:58:00 CST 2019, time=2019-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1802045, encodeId=5403180204516, content=<a href='/topic/show?id=52b2e47257e' target=_blank style='color:#2F92EE;'>#禽流感病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74725, encryptionId=52b2e47257e, topicName=禽流感病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=37d0457, createdName=yhj-time, createdTime=Mon Jul 29 11:58:00 CST 2019, time=2019-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084448, encodeId=077420844482f, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Thu Aug 15 10:58:00 CST 2019, time=2019-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857707, encodeId=3580185e707b2, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Mon Jan 07 18:58:00 CST 2019, time=2019-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342522, encodeId=95fb1342522bd, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Thu Oct 11 09:58:00 CST 2018, time=2018-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573730, encodeId=cb8815e373078, content=<a href='/topic/show?id=8ffbe472637' target=_blank style='color:#2F92EE;'>#禽流感病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74726, encryptionId=8ffbe472637, topicName=禽流感病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=847a15925078, createdName=venlin, createdTime=Thu Oct 11 09:58:00 CST 2018, time=2018-10-11, status=1, ipAttribution=)]
    2018-10-11 12498dabm77暂无昵称

    #变异#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1961179, encodeId=b34a19611e94d, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Thu Oct 18 06:58:00 CST 2018, time=2018-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870908, encodeId=a35a18e090857, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Jan 26 17:58:00 CST 2019, time=2019-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1802045, encodeId=5403180204516, content=<a href='/topic/show?id=52b2e47257e' target=_blank style='color:#2F92EE;'>#禽流感病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74725, encryptionId=52b2e47257e, topicName=禽流感病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=37d0457, createdName=yhj-time, createdTime=Mon Jul 29 11:58:00 CST 2019, time=2019-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084448, encodeId=077420844482f, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Thu Aug 15 10:58:00 CST 2019, time=2019-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857707, encodeId=3580185e707b2, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Mon Jan 07 18:58:00 CST 2019, time=2019-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342522, encodeId=95fb1342522bd, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Thu Oct 11 09:58:00 CST 2018, time=2018-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573730, encodeId=cb8815e373078, content=<a href='/topic/show?id=8ffbe472637' target=_blank style='color:#2F92EE;'>#禽流感病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74726, encryptionId=8ffbe472637, topicName=禽流感病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=847a15925078, createdName=venlin, createdTime=Thu Oct 11 09:58:00 CST 2018, time=2018-10-11, status=1, ipAttribution=)]
    2018-10-11 venlin

    #禽流感病毒#

    0