J Affect Disord:筛选抑郁症患者认知功能的工具——SCIP-D和COBRA

2015-11-30 phylis 译 MedSci原创

背景:单相抑郁症持续性认知功能障碍(UD)可致社会职业功能受损,但没有可行的方法来筛选和监控抑郁症患者的认知功能障碍。本研究调查两个新的工具筛选UD的认知功能障碍的有效性,及其与社会职业能力的关系。方法:UD部分或者完全缓解组(n = 53)和健康对照者(n = 103)。应用两个新的筛选工具,丹麦精神病学认知损害筛查(SCIP-D)和双相情感障碍等级评估认知部分(COBRA)及已经确定的神经心理

背景:单相抑郁症持续性认知功能障碍(UD)可致社会职业功能受损,但没有可行的方法来筛选和监控抑郁症患者的认知功能障碍。本研究调查两个新的工具筛选UD的认知功能障碍的有效性,及其与社会职业能力的关系。

方法:UD部分或者完全缓解组(n = 53)和健康对照者(n = 103)。应用两个新的筛选工具,丹麦精神病学认知损害筛查(SCIP-D)和双相情感障碍等级评估认知部分(COBRA)及已经确定的神经心理和自评方法对两组进行评估。应用哈密尔顿抑郁量表及功能评估量表分别对两组受试者进行抑郁症状和社会职业功能评估。

结果:SCIP-D和COBRA是客观和主观的认知障碍功能受损的有效检测方法。三种SCIP-D的形式是相似的。SCIP-D和COBRA检测客观认知功能损伤时显示出较高的敏感性及良好的特异性(分别为91%和70%)。与客观认知功能困难相比,社会职业功能受损与主观认知困难((r= 0.7))相关,客观认知困难与管理技能方面存在弱的相关性(r= 0.3)。

限制:样本量较小。

结论:SCIP-D和COBRA是客观和主观的认知障碍功能受损的有效检测方法,可应用于UD患者认知功能障碍的筛查。

原始出处:

Ott CV, Bjertrup AJ, Jensen JH, et al. Screening for cognitive dysfunction in unipolar depression: Validation and evaluation of objective and subjective tools. J Affect Disord. 2015 Nov 10.


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    2016-06-29 cmsvly
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    2016-01-28 chenwq08
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