Am J Otolaryngol:在萎缩性鼻炎中局部丝裂霉素C使用能够协助碱性鼻洗利福平治疗

2019-02-16 AlexYang MedSci原创

原发萎缩性鼻炎(PAR)是一种常见的古老疾病。最近,有研究人员调查了局部丝裂霉素C作为一种辅助药物对PAR患者主管和客观改善中的作用。研究是一个前瞻性的随机对照研究,在一个高级医院中进行,时间为2016年1月到2018年3月。研究包括了50名年龄在18岁到45岁的患有PAR的患者,并随机分成2组。2个小组分为对照组和丝裂霉素溶解于含有利福平碱性溶液碱洗组,对照组则只用含有利福平的碱性溶液碱洗。12

原发萎缩性鼻炎(PAR)是一种常见的古老疾病。最近,有研究人员调查了局部丝裂霉素C作为一种辅助药物对PAR患者主管和客观改善中的作用。

研究是一个前瞻性的随机对照研究,在一个高级医院中进行,时间为2016年1月到2018年3月。研究包括了50名年龄在18岁到45岁的患有PAR的患者,并随机分成2组。2个小组分为对照组和丝裂霉素溶解于含有利福平碱性溶液碱洗组,对照组则只用含有利福平的碱性溶液碱洗。12周治疗后,研究人员对2个小组中相关症状的主观和客观评分进行了评估。研究发现,与对照组相比,丝裂霉素辅助治疗组的壳化程度和鼻出血严重度(p<0.0001)均显著改善,并且分泌物明显恢复正常(p<0.0001)。另外,2个小组中的主观和客观评估得分均具有显著改善。

最后,研究人员指出,在患有萎缩性鼻炎的患者中,丝裂霉素的使用能够产生更好的治疗效果。

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    2019-12-19 chendoc252
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    2019-02-18 chg122