LANCET INFECT DIS:在美国阿肯色州一个高接种率的马绍尔群岛的流行性腮腺炎的爆发报告

2019-02-02 MedSci MedSci原创

在2000年至15年期间,美国阿肯色州小石城的阿肯色州卫生部每年调查1到6例流行性腮腺炎。从2016年8月5日至2017年8月5日,该部门收到超过4000例疑似流行性腮腺炎病例的报告,这是在过去30年中美国第二大疫情爆发。 <span style="font-family:宋体;mso-ascii-font-family:Calibri; mso-ascii-theme-font:mino

2000年至15年期间,美国阿肯色州小石城的阿肯色州卫生部每年调查16例流行性腮腺炎。从201685日至201785日,该部门收到超过4000例疑似流行性腮腺炎病例的报告,这是在过去30年中美国第二大疫情爆发。

阿肯色州卫生部通过调查所有报告的腮腺炎病例,以确定暴露,旅行和疫苗接种史并确定密切接触者。如果患者经实验室确认有腮腺炎病毒,或者他们有临床症状以及阳性血清学检测或已确认病例有已知流行病学联系,则将病例分类为已确诊。

研究发现,爆发期间发现2954例与暴发有关的流行性腮腺炎:1665例(56%)经实验室确认,1676例(57%)为5-17儿童1692例(57%)为马绍尔人。在1676名学龄儿童中,1536名(92%)曾接受至少两剂含有腮腺炎病毒的疫苗。虽然报告了19例睾丸炎,但未发现严重的并发症。在Marshallese个体中观察到异常,例如复发性腮腺炎和长期病毒脱落。病毒样品的特征为基因型G.

研究表明,这次大规模疫情主要影响到一个家庭拥挤密集的边缘化社区,这突显了对协调,跨学科和非传统的疫情反应的需求。这次疫情引发了关于腮腺炎疫苗有效性和潜在的免疫力下降的问题。

原始出处:                                            

Virgie S Fields, MS, Mumps in a highly vaccinated Marshallese community in Arkansas, USA: an outbreak report.

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    2019-11-17 gous
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    2020-01-07 tulenzi
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    2019-09-10 howi
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    2019-02-04 mfx799

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