Neurology:经颅刺激能对脑损伤后意识障碍有益

2014-04-14 佚名 中国神经时讯

4月1日,在线发表于Neurology上的一项最新研究显示,经颅直流电刺激(tDCS)对那些严重脑损伤患者之后出现的意识障碍(DOCs)能够提供短期裨益。 研究人员报告,tDCS阳极刺激可用于提高部分处于最少意识状态(MCS)患者左背外侧额叶前皮质昏迷恢复量表的得分,而不产生不良反应。 研究共纳入30例处于MCS的患者与25例处于植物状态/无觉醒反应综合症(VS/UWS)的患者。脑损伤

4月1日,在线发表于Neurology上的一项最新研究显示,经颅直流电刺激(tDCS)对那些严重脑损伤患者之后出现的意识障碍(DOCs)能够提供短期裨益

研究人员报告,tDCS阳极刺激可用于提高部分处于最少意识状态(MCS)患者左背外侧额叶前皮质昏迷恢复量表的得分,而不产生不良反应。

研究共纳入30例处于MCS的患者与25例处于植物状态/无觉醒反应综合症(VS/UWS)的患者。脑损伤的原因包括外伤、缺氧、脑血管事件及蛛网膜下腔出血。

Cyclotron研究中心的资深作家Steven Laureys博士介绍说:“我们的研究揭示了那些处于MCS患者的神经可塑性和意识信号的短暂恢复,但并不能做出任何可能有关tDCS长期效益的声明。”

每位患者接受20分钟的tDCS阳性刺激和伪刺激。tDCS是一种非侵入性皮层刺激,通过弱强度电流调节刺激部位大脑皮层的兴奋性。

刺激装置包括一个内置安慰剂模式。患者及管理人员均不知道是假刺激还是实际治疗。

治疗前评估或伪刺激前或后评估期间,VS/UWS组有2例急性(3个月以内)患者(8%)没有发现tDCS相关意识信号。该研究无治疗相关不良反应。

tDCS刺激较重复经颅磁刺激(rTMS)可能有一些优势,包括刺激部位神经元放电。作者说,tDCS刺激具有较少的不适,且引发癫痫的风险较低,因此它可能更容易申请。

原始出处:


Pauline Anderson.Transcranial Stimulation in Disorders of Consciousness. Medscape.April 03, 2014

Thibaut A1, Bruno MA, Ledoux D, Demertzi A, Laureys S.tDCS in patients with disorders of consciousness: Sham-controlled randomized double-blind study.Neurology. 2014 Apr 1;82(13):1112-8. doi: 10.1212/WNL.0000000000000260.


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