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Diabetes：脂肪干细胞外泌体通过促进巨噬细胞M2极化和白色脂肪组织米色化缓解脂肪炎症

2017-12-14 Johnny “外泌体之家”微信号

ADSCs外泌体肥胖
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脂肪干细胞（ADSCs）在控制肥胖相关的炎症和代谢紊乱中发挥重要作用。已知来自ADSCs的外泌体某几种疾病中发挥保护作用，但是它们在肥胖和相关病理状况中的作用仍不清楚。

脂肪干细胞（ADSCs）在控制肥胖相关的炎症和代谢紊乱中发挥重要作用。已知来自ADSCs的外泌体某几种疾病中发挥保护作用，但是它们在肥胖和相关病理状况中的作用仍不清楚。

山东大学王群副教授的研究表明用ADSC衍生的外泌体对肥胖小鼠的治疗促进了它们的代谢稳态，包括改善的胰岛素敏感性（改善了27.8％），减少了肥胖并且减轻了肝脂肪变性。ADSC衍生的外泌体驱动M2巨噬细胞极化、炎症减少和在饮食诱导的肥胖小鼠的白色脂肪组织（WAT）米色化。机制上，来自ADSCs的外泌体通过其携带的活性STAT3通过精氨酸酶-1的反式激活转移到巨噬细胞中以诱导抗炎的M2表型。此外，由ADSC衍生的外泌体诱导的M2巨噬细胞不仅表达高水平的负责儿茶酚胺释放的酪氨酸羟化酶，而且还促进ADSC增殖和乳酸产生，从而有利于响应高脂肪激发的WAT米色化和体内平衡。这些发现描绘了一种新的外泌体介导的ADSC-巨噬细胞串扰机制，其促进WAT中的免疫和代谢稳态，从而为肥胖和糖尿病提供潜在的治疗方案。

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    2018-08-16 ms9608593228839890

    #DIA#

    0

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    2018-10-31 木头人513

    #Diabetes#

    0

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    2018-07-01 兰亭序123

    学习了

    0

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createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Sat Jun 30 07:59:05 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327907, encodeId=fa8a32e907f0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Fri Jun 29 07:49:02 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327403, encodeId=b6b132e403c5, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Wed Jun 27 10:02:18 CST 2018, time=2018-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327104, encodeId=307132e10485, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Tue Jun 26 08:23:11 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326656, encodeId=45e43266564f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Sun Jun 24 16:02:00 CST 2018, time=2018-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325796, encodeId=1dbd325e96ad, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Thu Jun 21 09:21:09 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325549, encodeId=522a32554917, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Wed Jun 20 08:20:13 CST 2018, time=2018-06-20, status=1, ipAttribution=)]
    2018-06-30 兰亭序123

    学习了

    0

  5. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Wed Jun 27 10:02:18 CST 2018, time=2018-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327104, encodeId=307132e10485, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Tue Jun 26 08:23:11 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326656, encodeId=45e43266564f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Sun Jun 24 16:02:00 CST 2018, time=2018-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325796, encodeId=1dbd325e96ad, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Thu Jun 21 09:21:09 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325549, encodeId=522a32554917, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Wed Jun 20 08:20:13 CST 2018, time=2018-06-20, status=1, ipAttribution=)]
    2018-06-29 兰亭序123

    学习了

    0

  6. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Wed Jun 27 10:02:18 CST 2018, time=2018-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327104, encodeId=307132e10485, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Tue Jun 26 08:23:11 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326656, encodeId=45e43266564f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Sun Jun 24 16:02:00 CST 2018, time=2018-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325796, encodeId=1dbd325e96ad, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Thu Jun 21 09:21:09 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325549, encodeId=522a32554917, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Wed Jun 20 08:20:13 CST 2018, time=2018-06-20, status=1, ipAttribution=)]
    2018-06-27 兰亭序123

    学习了

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Sat Jun 30 07:59:05 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327907, encodeId=fa8a32e907f0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Fri Jun 29 07:49:02 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327403, encodeId=b6b132e403c5, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Wed Jun 27 10:02:18 CST 2018, time=2018-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327104, encodeId=307132e10485, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Tue Jun 26 08:23:11 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326656, encodeId=45e43266564f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Sun Jun 24 16:02:00 CST 2018, time=2018-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325796, encodeId=1dbd325e96ad, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Thu Jun 21 09:21:09 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325549, encodeId=522a32554917, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Wed Jun 20 08:20:13 CST 2018, time=2018-06-20, status=1, ipAttribution=)]
    2018-06-26 兰亭序123

    学习了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1638252, encodeId=2174163825294, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Thu Aug 16 18:23:00 CST 2018, time=2018-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901885, encodeId=5bae1901885b9, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Wed Oct 31 17:23:00 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328398, encodeId=1408328398bd, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Sun Jul 01 08:47:48 CST 2018, time=2018-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328147, encodeId=046832814e53, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Sat Jun 30 07:59:05 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327907, encodeId=fa8a32e907f0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Fri Jun 29 07:49:02 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327403, encodeId=b6b132e403c5, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Wed Jun 27 10:02:18 CST 2018, time=2018-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327104, encodeId=307132e10485, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Tue Jun 26 08:23:11 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326656, encodeId=45e43266564f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Sun Jun 24 16:02:00 CST 2018, time=2018-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325796, encodeId=1dbd325e96ad, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Thu Jun 21 09:21:09 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325549, encodeId=522a32554917, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Wed Jun 20 08:20:13 CST 2018, time=2018-06-20, status=1, ipAttribution=)]
    2018-06-24 兰亭序123

    学习了

    0

  9. 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createdBy=0045169, createdName=木头人513, createdTime=Wed Oct 31 17:23:00 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328398, encodeId=1408328398bd, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Sun Jul 01 08:47:48 CST 2018, time=2018-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328147, encodeId=046832814e53, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Sat Jun 30 07:59:05 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327907, encodeId=fa8a32e907f0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Fri Jun 29 07:49:02 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327403, encodeId=b6b132e403c5, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Wed Jun 27 10:02:18 CST 2018, time=2018-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327104, encodeId=307132e10485, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Tue Jun 26 08:23:11 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326656, encodeId=45e43266564f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Sun Jun 24 16:02:00 CST 2018, time=2018-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325796, encodeId=1dbd325e96ad, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Thu Jun 21 09:21:09 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325549, encodeId=522a32554917, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Wed Jun 20 08:20:13 CST 2018, time=2018-06-20, status=1, ipAttribution=)]
    2018-06-21 兰亭序123

    学习了

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1638252, encodeId=2174163825294, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Thu Aug 16 18:23:00 CST 2018, time=2018-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901885, encodeId=5bae1901885b9, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Wed Oct 31 17:23:00 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328398, encodeId=1408328398bd, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Sun Jul 01 08:47:48 CST 2018, time=2018-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328147, encodeId=046832814e53, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Sat Jun 30 07:59:05 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327907, encodeId=fa8a32e907f0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Fri Jun 29 07:49:02 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327403, encodeId=b6b132e403c5, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Wed Jun 27 10:02:18 CST 2018, time=2018-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327104, encodeId=307132e10485, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Tue Jun 26 08:23:11 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326656, encodeId=45e43266564f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Sun Jun 24 16:02:00 CST 2018, time=2018-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325796, encodeId=1dbd325e96ad, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Thu Jun 21 09:21:09 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=325549, encodeId=522a32554917, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er6Gnp47UKDBUh7BiadBKe2SjdBiaibNuYmwTGkrrE34N3iaoneZnFibSziaXicAMbqIkTod8ibbI9nTwOB7w/0, createdBy=9fa32173975, createdName=兰亭序123, createdTime=Wed Jun 20 08:20:13 CST 2018, time=2018-06-20, status=1, ipAttribution=)]
    2018-06-20 兰亭序123

    学习了

    0

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