Fertil Steril:深部直肠阴道子宫内膜异位症:药物治疗是更佳选择?

2018-01-20 林巧楠 环球医学网

发表于《Fertil Steril》上的一篇综述,介绍了药物治疗在深部直肠阴道子宫内膜异位症管理中的作用。

发表于《Fertil Steril》上的一篇综述,介绍了药物治疗在深部直肠阴道子宫内膜异位症管理中的作用。

确定药物治疗在深部直肠阴道子宫内膜异位症的女性中是否有效,以及在什么情况下可以认为药物治疗可以替代手术,对于患者和医生来说非常重要。众多的观察性研究和一些随机对照研究证实,不同的激素类药物可改善约三分之二深部直肠阴道子宫内膜异位症女性的疼痛和其他症状。由于未观察到各种化合物效应大小的主要差异,所以当患者咨询时,应该将重点放在用药安全性、耐受性和成本上。当计划长期治疗时,孕激素可以提供最佳的治疗平衡。应该告知女性,激素类药物可以控制但不能治愈子宫内膜异位症,为了避免手术,激素类药物治疗应该持续数年。对于肾盂积水、严重肠梗阻和想要自然受孕的女性,药物治疗并非手术的替代。在将来治疗深部子宫内膜异位症的新药的随机对照试验中,孕激素应该系统地选为对照药物。同时,应该优化现有药物的使用,药物和手术治疗应该视为阶梯式治疗。一般来说,没有绝对的最佳选择,一定要完全告知女性不同治疗选择的潜在获益、潜在危害和成本,并允许女性选择哪种治疗方法是她们认为更好的。

原始出处:
Vercellini P, Buggio L, Somigliana E.Role of medical therapy in the management of deep rectovaginal endometriosis.Fertil Steril. 2017 Dec;108(6):913-930. doi: 10.1016/j.fertnstert.2017.08.038.

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