Neurology:缺血性脑卒中后癫痫的发生率与治疗!

2017-08-24 xing.T MedSci原创

由于缺血性脑卒中后卒中相关的癫痫发作和癫痫负担是巨大。需要进一步的研究来确定缺血性卒中后癫痫的危险因素和最佳的二级预防。

近日,神经病学领域权威取杂志Neurology上发表了一篇荟萃分析文章,研究人员对缺血性卒中后早期和迟发性癫痫发作的发病率及其药物治疗进行了一项荟萃分析和系统评价。

研究人员将报告了缺血性卒中后癫痫发作发生率以及那些报告了对任何特定抗癫痫药物(AEDs)治疗反应的观察性研究纳入分析。研究人员通过预定义的研究特性来评估偏倚风险。对所有数据进行了随机效应荟萃分析,这些数据可用于分析早期和晚期卒中相关癫痫发作的发病率。研究人员采用I2统计来评估异质性,并使用预先设定的变量进行敏感性分析。对报告了采用AEDs治疗卒中相关的癫痫发作的研究进行定性合成。

研究人员从10554篇文献中筛选出了41项研究;35项研究报告了卒中相关癫痫发作的发生率,6项研究报告了特定抗癫痫药物的疗效。大多数研究为低等和中等质量研究。早期癫痫发作率为3.3%(95%可信区间为2.8%-3.9%,I2=92.8%),而迟发性癫痫或癫痫的发病率为每1000人中有18人每年(95%可信区间为1.5-2.2,I2=94.1%)。高度异质性不能通过敏感性分析进行解释。对于卒中相关癫痫发作的治疗,没有单一一种AED比其他AED更有效,尽管新的AEDs副作用较少。

由于缺血性脑卒中后卒中相关的癫痫发作和癫痫负担是巨大。需要进一步的研究来确定缺血性卒中后癫痫的危险因素和最佳的二级预防

原始出处:


Jeffrey Z. Wang,et al. Incidence and management of seizures after ischemic stroke Systematic review and meta-analysis.Neurology. 2017. http://dx.doi.org/10.1212/WNL.0000000000004407

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    2018-07-07 yinhl1978
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    2017-08-26 Johnson_zhangdr

    这种方法值得学习.

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1671309, encodeId=f3f116e130921, content=<a href='/topic/show?id=9f4e360191a' target=_blank style='color:#2F92EE;'>#卒中后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36019, encryptionId=9f4e360191a, topicName=卒中后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff7426824786, createdName=waiwai3039, createdTime=Thu Jan 11 08:14:00 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1826378, encodeId=ebea18263e8c8, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Fri Jan 12 17:14:00 CST 2018, time=2018-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892932, encodeId=1ba71892932a4, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sun Mar 18 18:14:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1807234, encodeId=b660180e23437, content=<a href='/topic/show?id=6eade9380cb' target=_blank style='color:#2F92EE;'>#缺血性脑卒中后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79380, encryptionId=6eade9380cb, topicName=缺血性脑卒中后)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b3ad2500191, createdName=12498dd9m11暂无昵称, createdTime=Tue Feb 13 15:14:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1807064, encodeId=713f180e06462, content=<a href='/topic/show?id=245de9378aa' target=_blank style='color:#2F92EE;'>#缺血性脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79378, encryptionId=245de9378aa, topicName=缺血性脑)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLGtr9t89oicQdQSIeKmOQic1weIWfibJ7H24XnT8ic9wiaUMTnXByenuwicOj8Jib42ibHXNptnuiaKthhiaVw/132, createdBy=ac342500190, createdName=ms7524819409032184, createdTime=Fri Dec 29 05:14:00 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000079, encodeId=b2b820000e92d, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sat Jul 07 18:14:00 CST 2018, time=2018-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237159, encodeId=1cb123e1594d, content=这种方法值得学习., beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5WdRCZb0Hs1YiaOB88m23a0oYulDm9Z0Es2N8rk8dmG1tkgXOibgBGBTMpwlof4aic6HdrIeR2zF09okwsgRbedK0/0, createdBy=72f41927023, createdName=Johnson_zhangdr, createdTime=Sat Aug 26 02:57:11 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236881, encodeId=d45d236881ad, content=这样的文章应该翻译的在细致一些, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Fri Aug 25 07:02:55 CST 2017, time=2017-08-25, status=1, ipAttribution=)]
    2017-08-25 baihao215

    这样的文章应该翻译的在细致一些

    0

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