JCO:肥胖是硬伤!男性癌症幸存者要注意

2017-03-21 佚名 环球医学

2016年12月,发表在《J Clin Oncol》的一项由韩国科学家进行的研究考察了男性癌症幸存者确诊前体质指数对第二次原发癌风险的影响。

2016年12月,发表在《J Clin Oncol》的一项由韩国科学家进行的研究考察了男性癌症幸存者确诊前体质指数对第二次原发癌风险的影响。



目的:男性癌症幸存者比普通人群有着更高的癌症风险,该风险或由肥胖或肥胖相关致癌易感性增加所致。研究者评价了第一次癌症确诊前的肥胖对幸存者第二次原发癌(SPCs)的影响。

方法:研究人群涉及2003年1月至2010年12月期间239615例韩国男性癌症幸存者。评价随访期至2011年12月期间的SPCs发生率。使用Cox比例风险模型,计算确诊前体质指数(BMI)相关SPCs的风险比,并与全部队列中第一次癌症患者进行比较。

结果:随访1614583人-年后,研究者考察了4799例SPC患者。癌症幸存者中的年龄标准化癌症率为普通人群的1.1倍。研究者发现,确诊前BMI与所有联合、结直肠、肝、淋巴、胆道、肾脏和肥胖相关SPCs风险之间存在正向线性趋势。男性癌症幸存者中的BMI-SPC风险相关性维度强于普通人群中BMI与首次原发癌的相关性,但两组的平均BMI相似。在重度肥胖等级(BMI≥30 kg/m2)中,癌症幸存者的SPCs校正风险比(1.41;95% CI,1.15~1.74)显着高于队列所有受试者(1.12;95% CI,1.09~1.16;P异质性<0.01)。

结论:确诊前,肥胖是总体和个体SPCs的一个风险因素。与普通人群相比,BMI的强度与癌症的相关性在男性癌症幸存者中略为明显。

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    2017-10-11 lidong40
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    2017-03-22 大爰

    健康生活方式是防病的要务!

    0

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    2017-03-21 1e15b6fem30(暂无匿称)

    很好的学习资料,谢谢了。

    0

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