BMC Infect Dis:瞬时弹性成像用于评估存在肝硬化的HIV/HCV共感染患者疾病预后,是无效的

2018-04-21 MedSci MedSci原创

TE对于评估失代偿性肝硬化患者的预后是无效的。白蛋白浓度和Child-Pugh评分是评估这个人群中死亡率较好的预测因子。

研究背景:对于采用瞬时弹性成像(TE)评估失代偿性肝硬化患者疾病预后,目前所知甚少。

研究方法:本研究分析了2006年至2015年期间,接受瞬时弹性成像检测作为常规随访内容的存在肝硬化失代偿的HIV/HCV共感染患者。研究还计算了肝脏的脾脏直径-血小板评分(LSPS),FIB-4指数,白蛋白,MELD评分和Child-Pugh评分。研究主要结果为死亡率。

研究结果:研究人群包括65例患者。在第一次进行瞬时弹性成像检测后的中位随访时间为32个月时,17例患者接受了抗HCV治疗,31例患者发生死亡。预测死亡最好的因素是白蛋白,其受试者工作特征曲线下面积为0.695;其次是Child-Pugh评分,其受试者工作特征曲线下面积为0.648,P值均< 0.05。MELD 评分、瞬时弹性成像、LSPS 评分和FIB-4的受试者工作特征曲线下面积较少,分别为0.633,0.618,0.595和0.569,P均大于0.05。单变量Cox回归分析表明,白蛋白、FIB-4、Child-Pugh评分、MELD评分等,而非TE,均与死亡相关。多变量分析表明,白蛋白和Child-Pugh评分是唯一与死亡相关的基线变量。

研究结论:本研究结果表明,TE对于评估失代偿性肝硬化患者的预后是无效的。白蛋白浓度和Child-Pugh评分是评估这个人群中死亡率较好的预测因子。

原始出处:

Perez-Latorre L, Sanchez-Conde M, Miralles P, et al. Prognostic value of liver stiffness in HIV/HCV-Coinfected patients with decompensated cirrhosis. BMC Infect Dis, 2018, 18(1), 170. doi: 10.1186/s12879-018-3067-z.

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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308078, encodeId=d5a73080e8de, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sun Apr 22 06:08:52 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307934, encodeId=e2ac30e93460, content=不错.学习了.做笔记了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, 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  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308078, encodeId=d5a73080e8de, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sun Apr 22 06:08:52 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307934, encodeId=e2ac30e93460, content=不错.学习了.做笔记了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, 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  6. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308078, encodeId=d5a73080e8de, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sun Apr 22 06:08:52 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307934, encodeId=e2ac30e93460, content=不错.学习了.做笔记了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, 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  7. 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href='/topic/show?id=908be07412a' target=_blank style='color:#2F92EE;'>#疾病预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70741, encryptionId=908be07412a, topicName=疾病预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b25634523578, createdName=ms2694732865965676, createdTime=Sat Jun 30 01:52:00 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257731, encodeId=ff20125e7313c, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=460849, createdName=ymljack, createdTime=Mon Apr 23 02:52:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308078, encodeId=d5a73080e8de, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sun Apr 22 06:08:52 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307934, encodeId=e2ac30e93460, content=不错.学习了.做笔记了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Apr 21 14:22:35 CST 2018, time=2018-04-21, status=1, ipAttribution=)]
    2018-04-23 ymljack
  8. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308078, encodeId=d5a73080e8de, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sun Apr 22 06:08:52 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307934, encodeId=e2ac30e93460, content=不错.学习了.做笔记了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Apr 21 14:22:35 CST 2018, time=2018-04-21, status=1, ipAttribution=)]
    2018-04-22 changjiu

    学习一下谢谢

    0

  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308078, encodeId=d5a73080e8de, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sun Apr 22 06:08:52 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307934, encodeId=e2ac30e93460, content=不错.学习了.做笔记了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Apr 21 14:22:35 CST 2018, time=2018-04-21, status=1, ipAttribution=)]
    2018-04-21 虈亣靌

    不错.学习了.做笔记了.谢谢分享!

    0

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