Heart:GGT高水平与偶发心衰相关

2012-11-16 高晓方译 医学论坛网

  在芬兰人群中的一项研究表明,中、高水平血清γ-谷氨酰转肽酶(GGT)与偶发性心衰显著相关,并且在60岁以下人群中更具预测价值。论文于2012年11月9日在线发表于《心脏》(Heart)杂志。   此项基于人群的前瞻性队列研究共纳入18353例芬兰男性和19726例芬兰女性;受试者年龄为25~74岁,并且基线时均无心衰。主要转归指标为平均随访14.5年间的心衰发生情况。基线时不同水平的血清GG

  在芬兰人群中的一项研究表明,中、高水平血清γ-谷氨酰转肽酶(GGT)与偶发性心衰显著相关,并且在60岁以下人群中更具预测价值。论文于2012年11月9日在线发表于《心脏》(Heart)杂志。

  此项基于人群的前瞻性队列研究共纳入18353例芬兰男性和19726例芬兰女性;受试者年龄为25~74岁,并且基线时均无心衰。主要转归指标为平均随访14.5年间的心衰发生情况。基线时不同水平的血清GGT被用于预测偶发性心衰。

  结果显示,对年龄、性别、研究区域和时间、吸烟、教育、饮酒、体力活动、心瓣膜病、体质指数(BMI)、收缩压、基线总胆固醇以及基线和随访时心梗与糖尿病进行多变量校正之后,5组GGT(25、50、75和90百分位数)的心衰风险比分别为1.00、1.16、1.20、1.29 和1.82(P趋势<0.001)。依据吸烟状况、饮酒和BMI分层后得出了与之相似的结果。然而,60岁以下受试者的上述相关性强于60岁以上受试者。

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1763352, encodeId=6c7d1e63352aa, content=<a href='/topic/show?id=b190e99445' target=_blank style='color:#2F92EE;'>#GGT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7994, encryptionId=b190e99445, topicName=GGT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fa3237493049, createdName=ms4964546379600229, createdTime=Sun Oct 06 12:07:00 CST 2013, time=2013-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355697, encodeId=7c91135569e6d, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Nov 18 06:07:00 CST 2012, time=2012-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562113, encodeId=8acf1562113d9, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Sun Nov 18 06:07:00 CST 2012, time=2012-11-18, status=1, ipAttribution=)]
    2012-11-18 zhaojie88
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    2012-11-18 slcumt