Obstet Gynecol:妊娠期高血压疾病孕妇服用非甾体类抗炎药与产后血压有何关系?

2018-11-12 xing.T MedSci原创

由此可见,妊娠期高血压疾病孕妇产后服用非甾体类抗炎药与血压变化或抗高血压药物需求无关。

近日,妇产科权威杂志Obstetrics and Gynecology上发表了一研究文章,研究人员旨在评估产后非甾体类抗炎药(NSAID)是否与妊娠期高血压疾病患者血压升高有关,并评估服用NSAID与阿片类药物之间的关系。

研究人员对妊娠期高血压疾病孕妇进行了一项回顾性队列研究。根据患者是否在产后接受NSAIDs治疗分为两组进行分析。研究参与者为2008年至2015年期间在三级医疗中心分娩的孕妇。主要结局为产后期平均动脉压的变化。次要结局是产后疼痛评分、累积的产后阿片类药物需求、抗高血压药物服用或剂量增加以及产后不良结局,包括急性肾功能衰竭、血细胞比容的变化和高血压疾病孕妇再入院。

该研究共纳入了276名患有妊娠期高血压疾病的孕妇(129名未服用NSAID,147名服用NSAID)。与未服用NSAID的孕妇相比,产后服用NSAID与平均动脉压统计学显著变化之间无关(-0.7 vs. -1.8;平均差异为1.10,95%CI为-1.44至3.64)。类似地,在服用抗高血压药或剂量增加或高血压疾病孕妇再入院方面,队列之间没有观察到差异。该研究不足以确定服用NSAID是否与较低频率的次要结局(例如,急性肾功能不全的发生率、产后输血)或累积阿片类药物使用的任何差异相关。

由此可见,妊娠期高血压疾病孕妇产后服用非甾体类抗炎药与血压变化或抗高血压药物需求无关。

原始出处:
 
Anastasio, Hannah B, et al.Nonsteroidal Antiinflammatory Drug Administration and Postpartum Blood Pressure in Women With Hypertensive Disorders of Pregnancy.Obstetrics & Gynecology.2018. https://journals.lww.com/greenjournal/Abstract/publishahead/Nonsteroidal_Antiinflammatory_Drug_Administration.97891.aspx
 
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