Gastroenterology:腺瘤切除后结肠癌及相关死亡风险研究

2019-10-05 MedSci MedSci原创

经过长达14年的随访研究,仅高风险腺瘤人群的结肠镜癌发病及死亡风险显著增加

直肠癌(CRC)和与腺瘤切除相关死亡的长期风险尚不确定。近日研究人员基于社区的大型综合医疗环境数据,通过基线结肠镜腺瘤发现来考察CRC和相关死亡的风险。


2004-10年间,21个医疗中心参与研究,结肠镜检查结果包括无腺瘤、低风险腺瘤或高危腺瘤,随访至CRC诊断或死亡。


64422名参与者,其中女性占54.3%,平均年龄61.6岁,平均随访8.1年。相比于基线未发现腺瘤人群(45881例),高风险腺瘤组(7563例)患者CRC(HR=2.61)以及CRC相关死亡(HR=3.94)风险显著增加,而低风险腺瘤组患者的CRC以及相关死亡风险未见显著变化(HR=1.29;0.65)。


经过长达14年的随访研究,仅高风险腺瘤人群的结肠镜癌发病及死亡风险显著增加。


原始出处:


Jeffrey K. Lee et al. Long-term Risk of Colorectal Cancer and Related Death After Adenoma Removal in a Large, Community-based Population.Gastroenterology. October 2019.


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