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J Gen Appl Microbiol：乳酸乳球菌或是预防和治疗牙周炎和口臭的有益益生菌

2018-01-26 MedSci MedSci原创

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乳酸乳球菌是产生各种细菌素的一种益生菌。牙周病原体通过脂多糖（LPS）和胰蛋白酶样酶的作用诱导炎症和口臭。本研究旨在探究乳酸乳球菌对牙周病生物活性的抑制作用。为了研究乳酸乳球菌的抗微生物肽，通过离心收集乳酸乳球菌的废培养基（SCM），用或不用蛋白酶K处理，并评价SCM对牙周病病原体的抗菌活性。为了评估乳酸乳球菌对口臭的中和作用，将牙周病原体的SCM与乳酸乳球菌悬液混合，并通过气相色谱法测量挥发性硫

乳酸乳球菌是产生各种细菌素的一种益生菌。牙周病原体通过脂多糖（LPS）和胰蛋白酶样酶的作用诱导炎症和口臭。本研究旨在探究乳酸乳球菌对牙周病生物活性的抑制作用。

为了研究乳酸乳球菌的抗微生物肽，通过离心收集乳酸乳球菌的废培养基（SCM），用或不用蛋白酶K处理，并评价SCM对牙周病病原体的抗菌活性。为了评估乳酸乳球菌对口臭的中和作用，将牙周病原体的SCM与乳酸乳球菌悬液混合，并通过气相色谱法测量挥发性硫化合物（VSC）的水平。用少量修饰的LPS提取试剂盒提取牙周病原体中的LPS，并且在存在或不存在UV杀死的乳酸乳球菌的情况下，用提取的LPS处理作为单核细胞系的THP-1细胞。通过ELISA分析炎性细胞因子的产生。

结果显示，L.lactis的SCM显示对牙周病原体的抗微生物活性，而蛋白酶K处理的SCM显示出很小的抗微生物活性。此外，乳酸乳球菌悬浮液对牙周病菌产生的VSCs具有中和作用，紫外线杀死的乳酸乳球菌可抑制LPS诱导的IL-6和TNF-α的产生。

综上所述，该研究结果表明，乳酸乳球菌可能是预防和治疗牙周炎和口臭的有益益生菌。

原始出处：

Shin HS, Baek DH, Lee SH. Inhibitory effect of Lactococcus lactis on the bioactivity of periodontopathogens. J Gen Appl Microbiol. 2018 Jan 25. doi: 10.2323/jgam.2017.06.003.

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    2018-06-02 sunylz

    #Bio#

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    2018-12-10 xjy02

    #Micro#

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    #Biol#

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1917903, encodeId=a9b7191e9039b, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Jun 02 01:38:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084321, encodeId=c2a220843212b, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Mon Dec 10 16:38:00 CST 2018, time=2018-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857562, encodeId=c081185e56205, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Thu Feb 01 22:38:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767369, encodeId=742f1e6736987, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Wed Dec 12 18:38:00 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450742, encodeId=e53e1450e42ed, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Sun Jan 28 13:38:00 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282364, encodeId=079728236426, content=乳酸乳球菌是产生各种细菌素的一种益生菌.牙周病原体通过脂多糖(LPS)和胰蛋白酶样酶的作用诱导炎症和口臭.本研究旨在探究乳酸乳球菌对牙周病生物活性的抑制作用., beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri Jan 26 23:31:55 CST 2018, time=2018-01-26, status=1, ipAttribution=)]
    2018-01-28 liuyong2982

    #牙周#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1917903, encodeId=a9b7191e9039b, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Jun 02 01:38:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084321, encodeId=c2a220843212b, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Mon Dec 10 16:38:00 CST 2018, time=2018-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857562, encodeId=c081185e56205, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Thu Feb 01 22:38:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767369, encodeId=742f1e6736987, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Wed Dec 12 18:38:00 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450742, encodeId=e53e1450e42ed, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Sun Jan 28 13:38:00 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282364, encodeId=079728236426, content=乳酸乳球菌是产生各种细菌素的一种益生菌.牙周病原体通过脂多糖(LPS)和胰蛋白酶样酶的作用诱导炎症和口臭.本研究旨在探究乳酸乳球菌对牙周病生物活性的抑制作用., beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri Jan 26 23:31:55 CST 2018, time=2018-01-26, status=1, ipAttribution=)]
    2018-01-26 有备才能无患

    乳酸乳球菌是产生各种细菌素的一种益生菌.牙周病原体通过脂多糖(LPS)和胰蛋白酶样酶的作用诱导炎症和口臭.本研究旨在探究乳酸乳球菌对牙周病生物活性的抑制作用.

    0