PLoS One:妊娠期糖尿病女性的体能与瘦素和2型糖尿病风险的研究

2017-06-18 fengxiangxin MedSci原创

低体能(PF)是2型糖尿病(T2D)的危险因素之一。有妊娠期糖尿病 (GDM)史的妇女有在较年轻时患T2D的风险。但体能(PF)因素在GDM到T2D中所扮演的角色尚不明确。在先前的研究中,发现PF与血浆瘦素呈负相关。此项研究探讨了相比正常妊娠妇女,有GDM的妊娠妇女PF是否更低,以及独立于体脂水平,PF与血浆瘦素是否相关。

[引言]关于瘦素:美国NBC电视真人秀节目《超级减肥王》中选手们BMI普遍超过40,在节目结束时,选手普遍减掉原先30-50%的体重。在Obesity期刊上发表的一篇论文称在跟踪了这些选手6年之后,研究者得出了令人伤心的结论-他们千辛万苦减下的肉,绝大部分又长了回来(14人里只有1人成功保住了减肥成果,其他人全部复胖,6年中平均反弹7成,有些人甚至比参赛前更胖),尽管他们一直为保持身材而努力着。最惨的是,掉下去的体重反弹了,掉下去的静止代谢率却没有反弹(我们在忍饥挨饿时,静止代谢率会下降,以适应生存),这意味着他们每天基本得少吃一顿饭,才能阻止自己继续发胖。复胖的原因除了新陈代谢较低之外,可能是他们的瘦素水平暴跌(赛末时甚至跌到只有赛前的6%,赛后,他们不再那么极端节食,瘦素水平也缓慢回升,但最高只恢复到了赛前的67%),这意味着他们少有饱足感,他们一直处在饥饿中。同时,他们还会比一般人更渴望高油高糖的垃圾食品以激活大脑的奖赏中心)。顺便帮懒虫和馋鬼申明一下:你变胖的锅我们不背!通过这个减肥故事以及有趣的研究,我们了解了瘦素的一个方面,接下来的研究我们将了解瘦素可能与2型糖尿病(T2D)有关的另一个研究。

低体能(PF)是2型糖尿病(T2D)的危险因素之一。有妊娠期糖尿病 (GDM)史的妇女有在较年轻时患T2D的风险。但体能(PF)因素在GDM到T2D中所扮演的角色尚不明确。在先前的研究中,发现PF与血浆瘦素呈负相关。此项研究探讨了相比正常妊娠妇女,有GDM的妊娠妇女PF是否更低,以及独立于体脂水平,PF与血浆瘦素是否相关。

在PPS-Diab研究中连续招募了2011-2016年的236名参与者进行横截面分析(分娩后3-16个月的妇女组成的队列研究,152位妊娠期糖尿病(pGDM)后的妇女构成试验组,84位正常妊娠后的妇女构成对照组)。分析内容包括病史、体格检查和生物电阻抗分析(BIA)、全身磁共振成像(MRI)(n = 154)、5点口服葡萄糖耐量试验(分别于服糖前和服糖后30分钟、60分钟、120分钟、180分钟5个时间点测量血糖)、心肺运动试验;临床生化包括空腹血浆瘦素;统计分析包括M-W U检验和t检验、Spearman相关系数和多元线性回归分析。

pGDM组女性有较低的最大摄氧量[峰值VO2 /公斤:25.7(21.3-29.9) vs 30(26.6-34.1)毫升/分钟/公斤;总VO2peak:1733(1552-2005) vs 1970(1767-2238)毫升/分钟;P<0.0001]和较低的最大运动负荷(122.5(105.5-136.5) vs 141(128.5-159.5)W,P<0.0001)。空腹血浆瘦素与PF呈负相关(ρ= -0.72,P<0.0001和ρ= -0.16 P = 0.015;最大负荷ρ= -0.35, P<0.0001)。依据身体质量指数(BMI)和体脂量(BIA)对结果进行调整之后,联系依然比较明显。

最近有妊娠期糖尿病(GDM)病史的女性体能(PF)较正常对照组更低,因此,低体能( PF)可能是GDM后T2D的风险因素,应该进一步设立干预研究检验这个结果。低体能还独立于体脂,和瘦素水平增加有关,因此,推测体能PF可能通过某种机制影响瘦素信号转导,这个假设还需要进一步研究验证。

原始出处:

Gar, C., M. Rottenkolber, H. Grallert, et al., Physical fitness and plasma leptin in women with recent gestational diabetes. PLoS One, 2017 Jun 13;12(6):e0179128. doi: 10.1371/journal.pone.0179128. eCollection 2017

本文系梅斯医学(MEDSCI)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1789984, encodeId=f8841e899846f, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Tue Mar 27 02:30:00 CST 2018, time=2018-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956287, encodeId=1cf4195628e8f, content=<a href='/topic/show?id=a74d1109c8' target=_blank style='color:#2F92EE;'>#2型糖尿病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1109, encryptionId=a74d1109c8, topicName=2型糖尿病风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Mon Apr 02 13:30:00 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1770504, encodeId=c8771e7050406, content=<a href='/topic/show?id=05fe2665508' target=_blank style='color:#2F92EE;'>#体能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26655, encryptionId=05fe2665508, topicName=体能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80ae38174281, createdName=liubm568, createdTime=Tue Sep 05 16:30:00 CST 2017, time=2017-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251046, encodeId=f2451251046d2, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Tue Jun 20 14:30:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253611, encodeId=5aae12536113b, content=<a href='/topic/show?id=9d5d44888a9' target=_blank style='color:#2F92EE;'>#妊娠期糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44888, encryptionId=9d5d44888a9, topicName=妊娠期糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Tue Jun 20 14:30:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366622, encodeId=44e8136662258, content=<a href='/topic/show?id=5065e125368' target=_blank style='color:#2F92EE;'>#瘦素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71253, encryptionId=5065e125368, topicName=瘦素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Tue Jun 20 14:30:00 CST 2017, time=2017-06-20, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1789984, encodeId=f8841e899846f, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Tue Mar 27 02:30:00 CST 2018, time=2018-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956287, encodeId=1cf4195628e8f, content=<a href='/topic/show?id=a74d1109c8' target=_blank style='color:#2F92EE;'>#2型糖尿病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1109, encryptionId=a74d1109c8, topicName=2型糖尿病风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Mon Apr 02 13:30:00 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1770504, encodeId=c8771e7050406, content=<a href='/topic/show?id=05fe2665508' target=_blank style='color:#2F92EE;'>#体能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26655, encryptionId=05fe2665508, topicName=体能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80ae38174281, createdName=liubm568, createdTime=Tue Sep 05 16:30:00 CST 2017, time=2017-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251046, encodeId=f2451251046d2, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Tue Jun 20 14:30:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253611, encodeId=5aae12536113b, content=<a href='/topic/show?id=9d5d44888a9' target=_blank style='color:#2F92EE;'>#妊娠期糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44888, encryptionId=9d5d44888a9, topicName=妊娠期糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Tue Jun 20 14:30:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366622, encodeId=44e8136662258, content=<a href='/topic/show?id=5065e125368' target=_blank style='color:#2F92EE;'>#瘦素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71253, encryptionId=5065e125368, topicName=瘦素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Tue Jun 20 14:30:00 CST 2017, time=2017-06-20, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1789984, encodeId=f8841e899846f, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Tue Mar 27 02:30:00 CST 2018, time=2018-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956287, encodeId=1cf4195628e8f, content=<a href='/topic/show?id=a74d1109c8' target=_blank style='color:#2F92EE;'>#2型糖尿病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1109, encryptionId=a74d1109c8, topicName=2型糖尿病风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Mon Apr 02 13:30:00 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1770504, encodeId=c8771e7050406, content=<a href='/topic/show?id=05fe2665508' target=_blank style='color:#2F92EE;'>#体能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26655, encryptionId=05fe2665508, topicName=体能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80ae38174281, createdName=liubm568, createdTime=Tue Sep 05 16:30:00 CST 2017, time=2017-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251046, encodeId=f2451251046d2, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Tue Jun 20 14:30:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253611, encodeId=5aae12536113b, content=<a href='/topic/show?id=9d5d44888a9' target=_blank style='color:#2F92EE;'>#妊娠期糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44888, encryptionId=9d5d44888a9, topicName=妊娠期糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Tue Jun 20 14:30:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366622, encodeId=44e8136662258, content=<a href='/topic/show?id=5065e125368' target=_blank style='color:#2F92EE;'>#瘦素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71253, encryptionId=5065e125368, topicName=瘦素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Tue Jun 20 14:30:00 CST 2017, time=2017-06-20, status=1, ipAttribution=)]
    2017-09-05 liubm568
  4. [GetPortalCommentsPageByObjectIdResponse(id=1789984, encodeId=f8841e899846f, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Tue Mar 27 02:30:00 CST 2018, time=2018-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956287, encodeId=1cf4195628e8f, content=<a href='/topic/show?id=a74d1109c8' target=_blank style='color:#2F92EE;'>#2型糖尿病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1109, encryptionId=a74d1109c8, topicName=2型糖尿病风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Mon Apr 02 13:30:00 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1770504, encodeId=c8771e7050406, content=<a href='/topic/show?id=05fe2665508' target=_blank style='color:#2F92EE;'>#体能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26655, encryptionId=05fe2665508, topicName=体能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80ae38174281, createdName=liubm568, createdTime=Tue Sep 05 16:30:00 CST 2017, time=2017-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251046, encodeId=f2451251046d2, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Tue Jun 20 14:30:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253611, encodeId=5aae12536113b, content=<a href='/topic/show?id=9d5d44888a9' target=_blank style='color:#2F92EE;'>#妊娠期糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44888, encryptionId=9d5d44888a9, topicName=妊娠期糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Tue Jun 20 14:30:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366622, encodeId=44e8136662258, content=<a href='/topic/show?id=5065e125368' target=_blank style='color:#2F92EE;'>#瘦素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71253, encryptionId=5065e125368, topicName=瘦素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Tue Jun 20 14:30:00 CST 2017, time=2017-06-20, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1789984, encodeId=f8841e899846f, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Tue Mar 27 02:30:00 CST 2018, time=2018-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956287, encodeId=1cf4195628e8f, content=<a href='/topic/show?id=a74d1109c8' target=_blank style='color:#2F92EE;'>#2型糖尿病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1109, encryptionId=a74d1109c8, topicName=2型糖尿病风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Mon Apr 02 13:30:00 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1770504, encodeId=c8771e7050406, content=<a href='/topic/show?id=05fe2665508' target=_blank style='color:#2F92EE;'>#体能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26655, encryptionId=05fe2665508, topicName=体能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80ae38174281, createdName=liubm568, createdTime=Tue Sep 05 16:30:00 CST 2017, time=2017-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251046, encodeId=f2451251046d2, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Tue Jun 20 14:30:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253611, encodeId=5aae12536113b, content=<a href='/topic/show?id=9d5d44888a9' target=_blank style='color:#2F92EE;'>#妊娠期糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44888, encryptionId=9d5d44888a9, topicName=妊娠期糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Tue Jun 20 14:30:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366622, encodeId=44e8136662258, content=<a href='/topic/show?id=5065e125368' target=_blank style='color:#2F92EE;'>#瘦素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71253, encryptionId=5065e125368, topicName=瘦素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Tue Jun 20 14:30:00 CST 2017, time=2017-06-20, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1789984, encodeId=f8841e899846f, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Tue Mar 27 02:30:00 CST 2018, time=2018-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956287, encodeId=1cf4195628e8f, content=<a href='/topic/show?id=a74d1109c8' target=_blank style='color:#2F92EE;'>#2型糖尿病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1109, encryptionId=a74d1109c8, topicName=2型糖尿病风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Mon Apr 02 13:30:00 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1770504, encodeId=c8771e7050406, content=<a href='/topic/show?id=05fe2665508' target=_blank style='color:#2F92EE;'>#体能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26655, encryptionId=05fe2665508, topicName=体能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80ae38174281, createdName=liubm568, createdTime=Tue Sep 05 16:30:00 CST 2017, time=2017-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251046, encodeId=f2451251046d2, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Tue Jun 20 14:30:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253611, encodeId=5aae12536113b, content=<a href='/topic/show?id=9d5d44888a9' target=_blank style='color:#2F92EE;'>#妊娠期糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44888, encryptionId=9d5d44888a9, topicName=妊娠期糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Tue Jun 20 14:30:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366622, encodeId=44e8136662258, content=<a href='/topic/show?id=5065e125368' target=_blank style='color:#2F92EE;'>#瘦素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71253, encryptionId=5065e125368, topicName=瘦素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Tue Jun 20 14:30:00 CST 2017, time=2017-06-20, status=1, ipAttribution=)]

相关资讯

ENDOCR J:维生素A与糖尿病的关系

一直以来,科学家们都不清楚维生素A与糖尿病之间的关系,但是最近的一项研究表明,维生素A可以改善胰岛素产生β-细胞的能力。

Neurology:海豹油给糖尿病患者带来的重要影响!

多伦多Krembil神经科学中心的一个研究小组发表了一篇文章,表明海豹油有可能有助于促进1型糖尿病患者的神经再生

血糖标准,可不是书上说的那么死板

糖尿病分为1型糖尿病、2型糖尿病和妊娠糖尿病,虽然同为糖尿病,但血糖控制标准大不相同。即使同为2型糖尿病,不同病情血糖控制的目标也不同。

JCEM:作用于胰岛素受体的人单克隆抗体——X358,安全性和耐受性良好

在糖尿病治疗方面,胰岛素分泌功能受损的患者需要一种新颖的改良的治疗模式。传统的单克隆抗体在配体 - 受体结合位点结合,以提供完全活化或类似开关的抑制。然而,受体也有很多位点,称为变构位点,它就像调节开关一样调节配体 - 受体之间相互作用。目前的研究已经发现了胰岛受体三种不同类别的变构抗体,并且他们发挥不同的作用。X358是一个作用于胰岛素受体(INSR)的人源性单克隆抗体,是胰岛素信号转导时的负别

糖友该多久查次血糖

有许多糖尿病患者都会问:我应该多长时间查一次血糖呢?其实这个问题不能一概而论。使用口服降糖药的糖友,在开始调整剂量的前两周,每周应连续测3天空腹、餐后2小时和睡前血糖,以便了解不同时间内血糖的控制情况,确定适宜的药物剂量。血糖稳定后,可每周测1天空腹、睡前和餐后2小时血糖。使用胰岛素的糖尿病患者,应在胰岛素作用的高峰时间测血糖。如使用中效胰岛素的患者应每天测2次血糖,可交替一天测早餐前和晚餐前血糖

N Engl J Med:卡格列净治疗2型糖尿病的安全性以及心血管事件和肾脏事件风险评估

卡格列净(Canagliflozin)属于选择性纳-葡萄糖共转运体2(SGLT2)抑制剂,通过阻断肾脏对血糖的重吸收及增加尿液中血糖的排泄,来降低机体血糖水平。同时卡格列净还能降低血压,减轻体重以及减少糖尿病患者的蛋白尿。研究者报告了卡格列净治疗的安全性以及对心血管、肾的影响。