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Current Biology:“俄罗斯方块”有助于改善成人弱视

2013-4-25 作者:Medscape   来源:医脉通 我要评论0
Tags: 俄罗斯方块  弱视  
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加拿大麦吉尔大学的研究人员使用流行的益智游戏“俄罗斯方块”治疗成人弱视,这项研究提供了直接证据:迫使双眼合作,可减轻对于弱视眼的抑制,增强大脑的可塑性,并且让大脑重新学习。研究结果发表在“Current Biology”杂志。
弱视是儿童视力障碍最常见的原因,影响了约3%的人群。大脑处理信息不佳,导致优势眼抑制弱视眼。以往的治疗主要靠遮盖优势眼,强迫弱视眼进行工作,但这种方法仅在儿童中有效,成人往往效果不佳。
“改善成人视力的关键在于为双眼提供合作的条件。”麦吉尔大学眼科研究所主任Robert Hess说。“成人的大脑具有相当程度的可塑性,这使得童年时视觉发育中断造成的后果有了治疗的可能。迫使眼睛共同努力,我们相信,将会改善弱视。”
研究人员使用视频游戏俄罗斯方块锻炼受试者,纳入18名弱视成人患者。9名患者使用弱视眼进行游戏,优势眼被遮盖;另外9名患者则双眼共同参与,但一只眼只能看到方块落下,另一只眼只能看到静止的背景平面。
两周后,后者弱视眼的视力和立体视觉明显改善。单眼组改为双眼训练后,视力也得到显著提高。
北美的一项临床试验将在今年晚些时候对这种疗法进行评估,以评价其对于儿童的适用性。


Lazy Eye Disorder Treated With Video Game Tetris
Apr. 22, 2013 — A research team led by Dr. Robert Hess from McGill University and the Research Institute of the McGill University Health Centre (RI-MUHC) has used the popular puzzle video game Tetris in an innovative approach to treat adult amblyopia, commonly known as "lazy eye." By distributing information between the two eyes in a complementary fashion, the video game trains both eyes to work together, which is counter to previous treatments for the disorder (e.g. patching).
This medical breakthrough provides direct evidence that alleviating suppression of the weaker eye, by forcing both eyes to cooperate, increases the level of plasticity in the brain and allows the amblyopic brain to relearn. The research is published in the  journal Current Biology.
Amblyopia is the most common cause of visual impairment in childhood, affecting up to 3 per cent of the population. It is caused by poor processing in the brain, which results in suppression of the weaker eye by the stronger eye. Previous treatments for the disorder, which have focused largely on covering the stronger eye in order to force the weaker eye to work, have proven only partially successful in children and have been ineffective in adults.
"The key to improving vision for adults, who currently have no other treatment options, was to set up conditions that would enable the two eyes to cooperate for the first time in a given task," says Dr. Robert Hess, senior author of the paper and Director of Research Department of Ophthalmology at the RI-MUHC and at McGill University.
According to Dr. Hess and his colleagues, the adult human brain has a significant degree of plasticity and this provides the basis for treating a range of conditions where vision has been lost as a result of a disrupted period of early visual development in childhood. The researchers examined the potential of treating amblyopic adults using the video game Tetris, which involves connecting different shaped blocks as they fall to the ground.
"Using head-mounted video goggles we were able to display the game dichoptically, where one eye was allowed to see only the falling objects, and the other eye was allowed to see only the ground plane objects," explains Dr. Hess, who also serves as director of McGill Vision Research. "Forcing the eyes to work together, we believed, would improve vision in the lazy eye."
The researchers tested a sample of 18 adults with amblyopia. Nine participants played the game monocularly with the weaker eye, while the stronger eye was patched; the other nine played the same game dichoptically, where each eye was allowed to view a separate part of the game. After two weeks, the group playing the dichoptic game showed a dramatic improvement in the vision of the weaker eye as well as in 3-D depth perception. When the monocular patching group, who had showed only a moderate improvement, was switched to the new dichoptic training, the vision of this group also improved dramatically.
The suitability of this treatment in children will be assessed later this year in a clinical trial across North America.



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