JAMA Intern Med:膳食中的农药残留与不孕不育

2017-10-31 zhangfan MedSci原创

研究发现,饮食中农药残留高导致辅助生殖失败风险增加。研究数据表明,人类接触范围内的膳食杀虫剂暴露可能与不良生殖后果有关

动物实验表明,环境中残留的农药摄入会导致实验动物后代存活率降低。近日研究人员考察了孕前水果和蔬菜中的农药摄入残留(FVS)对辅助生殖技术(ART)治疗不孕症结果的影响。

环境与生殖健康(EARTH)前瞻性队列研究于2007-16年间开展,325名参与妇女进行饮食评估,随后共进行了541次ART治疗。研究人员利用美国农业部农药残留监测数据将参与者体内农药摄入残留分为高残留和低残留组,利用聚类加权广义方程评估农药残留高低与ART结果的关系。研究的主要终点为每个ART治疗周期后临床妊娠和活产的调整概率。

325名参与者,平均年龄35.1岁,平均BMI为24.1,高残留组平均农药残留为2.8,低残留组为1.7。研究发现,高农药残留导致临床妊娠与活产率降低。相对于农药残留最低的1/4女性(<1.0),农药残留最高的1/4女性参与者(≥2.3),其临床妊娠概率降低了18%(95% CI,5%-30%),活产概率降低了26%(95% CI,13%-37%)。日常饮食中低农药残留食物不会影响ART结果。

研究发现,饮食中农药残留高导致辅助生殖失败风险增加。研究数据表明,人类接触范围内的膳食杀虫剂暴露可能与不良生殖后果有关。

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    2018-08-05 Homburg
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    2017-11-02 zhaojie88
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    2017-10-31 Y—xianghai

    学习了新知识

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