JAMA:VD3可降低早产儿反复喘息发作风险

2018-05-23 zhangfan MedSci原创

研究认为黑人早产儿接受额外的VD3补充可降低周岁后反复喘息发作风险

黑人早产儿在婴儿时期喘息发病率较高,补充维生素D可能通过调节肺和免疫系统对喘息产生影响。近日研究人员考察了VD3补充对早产儿反复喘息的治疗效果。

300名月龄28-36周的黑人早产儿参与研究,随机接受VD3补充(153例)或对照(147例),补充组接受400IU每天的VD3直至调整月龄6个月。研究的主要终点为调整月龄12个月后反复喘息发生率。

参与研究早产儿平均月龄33周,平均体重1.9Kg,92.3%的患儿完成研究。VD3补充组早产儿12个月反复喘息发作率为31.1%,对照组为41.8%(rr=0.66)。上呼吸道和下呼吸道感染是最常见的不良事件,其中VD3补充组上呼吸道感染率为54.9%,对照组为56.6%;下呼吸道感染率为21.6%,对照组为25.2%。

研究认为黑人早产儿接受额外的VD3补充可降低周岁后反复喘息发作风险。

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1613682, encodeId=1c07161368236, content=<a href='/topic/show?id=0ae0183205a' target=_blank style='color:#2F92EE;'>#VD3#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18320, encryptionId=0ae0183205a, topicName=VD3)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=417919401107, createdName=ms7899726347904398, createdTime=Fri May 25 01:55:00 CST 2018, time=2018-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317836, encodeId=630331e836cf, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed May 23 12:29:15 CST 2018, time=2018-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317825, encodeId=9b5c31e82543, content=有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83ervoOZpyH2LXoU7ibUK9xHSY6DEewrPsdic5ttTG2KKXsRBjeA5g8bkMicE9IiceAmCyxG0ekBzytPZSA/132, createdBy=78e22111987, createdName=1341f8d67dm, createdTime=Wed May 23 11:23:09 CST 2018, time=2018-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317822, encodeId=02e431e822e9, content=^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Wed May 23 11:02:17 CST 2018, time=2018-05-23, status=1, ipAttribution=)]
    2018-05-23 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

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    2018-05-23 1341f8d67dm

    有趣

    0

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    2018-05-23 wqkm

    ^_^^_^^_^

    0

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