2019年S​​OHO:Venetoclax联合Navitoclax治疗复发难治ALL和淋巴母细胞淋巴瘤前景光明

2019-09-16 Allan MedSci原创

根据2019年血液肿瘤学会(S​​OHO)年会上发表的一项研究,将venetoclax和navitoclax与化学疗法相结合,可以为复发难治急性淋巴细胞白血病(ALL)或淋巴母细胞淋巴瘤患者带来希望。

根据2019血液肿瘤学会(S​​OHO)年会上发表的一项研究,将venetoclaxnavitoclax与化学疗法相结合,可以为复发难治急性淋巴细胞白血病ALL)或淋巴母细胞淋巴瘤患者带来希望。德克萨斯大学安德森癌症中心的医学博士Elias Jabbour及其同事报告说,即使是先前经过干细胞移植患者,也可以看到很高的完全反应率。

对于该研究,患有复发难治ALL或淋巴母细胞淋巴瘤的患者接受体重调整的venetoclax(从第1天开始)和navitoclax(从第3天开始)结合化疗(研究者选择从第9天开始)。截至2019325日,已经治疗了16B细胞ALL患者、14T细胞ALL患者和2例淋巴母细胞淋巴瘤患者。中位先前治疗线为4。在16B细胞ALL患者中,5例(31%)完全缓解(CR)、2例(13%)CRi3例(19%)CRp2例(13%)有部分反应、3例(19%)病情稳定、1例(6%)疾病进展。


原始出处:

http://www.firstwordpharma.com/node/1666426#axzz5zU18ApSM

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    2020-06-08 canlab
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    2019-09-18 膀胱癌