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Radiology：自闭症儿童的脑白质异常

2018-05-01 shaosai MedSci原创

自闭症脑白质异常脑网络
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本研究旨在评价自闭症谱系障碍学龄前儿童脑白质连接网络的拓扑结构较一般发展（TD）儿童的差异性，并将结果发表在Radiology上。

本研究旨在评价自闭症谱系障碍学龄前儿童脑白质连接网络的拓扑结构较一般发展（TD）儿童的差异性，并将结果发表在Radiology上。

本研究共纳入了42名受试者，包括21名ASD患者（14名男性，平均年龄为4.56岁±0.97）和21名TD儿童（11名男性，平均年龄为5.13岁±0.82）。ASD诊断依靠DSM-MDGAF评分进行诊断（平均评分为8.00±0.50）。所有受试者行扩散张量成像（DTI）T2加权成像。利用图论分析来探究脑网络的拓扑结构。利用统计学分析比较两组差异性。

结果为，与TD组比较，ASD患者组特征路径长度变短(t 1 = 0.536、 t 2 = 0.534、 t 3 = 0.523、 t 4 = 0.510和 t 5 = 0.501； P < .05)、整体效率(t 1 = 0.499、 t 2 = 0.497、 t 3 = 0.486、 t 4 = 0.473和 t 5 = 0.465； P < .05)和类聚系数(t 1 = 0.673、 t 2 = 0.750、 t 3 = 0.757、 t 4 = 0.738和 t 5 = 0.741； P < .05)增加。在左侧苍白球(0.037 vs 0.032； P < .01)、右侧尾状核(0.037 vs 0.032； P < .01)的节点效率显着增加。

本研究表明，与TD儿童相比，ASD患者整体和局部脑网络拓扑结构发生改变，从而提示脑发育异常。基底节和边缘旁-边缘系统结构网络改变可能是学龄前ASD儿童的影像学标识物。

原始出处：

Li SJ， Wang Y， Qian L. et al.Alterations of White Matter Connectivity in Preschool Children with Autism Spectrum Disorder.Radiology.DOI： 10.1148/radiol.2018170059

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    2018-12-17 柳叶一刀

    #白质#

    0

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    2018-05-02 xiongke014

    #自闭#

    0

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    2018-05-01 131****1460

    学习了受益匪浅

    0

  4. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue May 01 07:17:33 CST 2018, time=2018-05-01, status=1, ipAttribution=)]
    2018-05-01 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

  5. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue May 01 07:17:33 CST 2018, time=2018-05-01, status=1, ipAttribution=)]
    2018-05-01 秀红

    学习了

    0

  6. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue May 01 07:17:33 CST 2018, time=2018-05-01, status=1, ipAttribution=)]
    2018-05-01 121832a9m88暂无昵称

    学习了

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue May 01 07:17:33 CST 2018, time=2018-05-01, status=1, ipAttribution=)]
    2018-05-01 陈文浩

    学习学生

    0

  8. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue May 01 07:17:33 CST 2018, time=2018-05-01, status=1, ipAttribution=)]
    2018-05-01 明月清辉

    谢谢分享.学习了

    0

  9. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue May 01 07:17:33 CST 2018, time=2018-05-01, status=1, ipAttribution=)]
    2018-05-01 wzb521zf

    一起学习学习

    0

  10. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue May 01 07:17:33 CST 2018, time=2018-05-01, status=1, ipAttribution=)]
    2018-05-01 龙胆草

    学习谢谢分享

    0

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自闭症日：一起关注自闭症的临床研究现状

闭症谱系障碍（Autism Spectrum Disorder，ASD）与多种症状相关，可以分为两大类：“核心”和“相关”。核心症状是社会交往和沟通障碍，以及重复行为和兴趣受限，所有这些都可以显著影响日常功能。相关症状包括焦虑，癫痫发作，语言障碍，感觉问题，注意力缺陷，情绪改变，睡眠不足，愤怒的爆发和自我伤害。

Transl Psychiat:情商竟然也看天生。。4万余人基因分析显示，共情能力10%来自遗传，与多种精神疾病相关

这几年，“原生家庭”这个词可是在网络上火了一把。正所谓你是你父母的投影。从个体的行为上，确实可以窥见家庭相处方式的一角。一个人是否能够体会他人的情绪，是否能够对此做出适当的回应，这些我们现在通常叫做情商的能力，与生长的环境是分不开的。

Molecular Autism：是否可以通过几何图像偏好来识别患有自闭症谱系障碍的婴幼儿？

在英国，大约每100个儿童中就有一个受到自闭症谱系障碍的影响。它以社交互动和交流困难加上进行重复性行为的偏好为特征。这种疾病的一个普遍症状是患儿对和其他孩子玩耍没有兴趣或不想跟其他孩子玩儿。但症状及其严重程度大不相同，从而给诊断带来困难。

位于生命两端：自闭症与阿尔茨海默氏症同待突破

4月2日是世界自闭症日。上海交通大学医学院附属新华医院发育行为儿童保健科主任李斐又将开始一周的诊疗工作。在所有儿童认知和行为问题中，自闭症是她最关注的一个

专家：中西医结合早期干预可显著改善自闭症症状

4月2日是第11个“世界提高自闭症意识日”。专家指出，中西医结合早期筛查、早期干预能够显著改善自闭症患儿的症状，提高患者生活质量和家庭幸福指数。