BMJ Open Gastroenterology:成年人慢性腹泻与非酒精性脂肪肝疾病和肥胖相关疾病的关系

2019-11-30 不详 MedSci原创

目前尚不清楚腹泻与肥胖或体重指数增加之间相关性的机制。本项研究旨在评估肠道与体重指数,代谢综合征(MS),非酒精性脂肪肝疾病(NAFLD)和其他肥胖相关疾病的关系。

背景及目的:
目前尚不清楚腹泻与肥胖或体重指数增加之间相关性的机制。本项研究旨在评估肠道与体重指数,代谢综合征(MS),非酒精性脂肪肝疾病(NAFLD)和其他肥胖相关疾病的关系。

方法:
研究人员收录于2005年至2010年间国家健康和营养库中的受试者进行了横断面分析。使用多项式逻辑回归检验疾病之间的关系关系。同时对人口统计学,吸烟,酒精和BMI等通过顺序建模进行了检验。

结果
在13413名成年人中,便秘和腹泻的患病率分别为8.9%和6.6%。在校正分析中,NAFLD在腹泻中比正常肠道模式(OR = 1.34,95%CI 1.01至1.78)或便秘(OR = 1.45,95%CI 1.03,2.03)更普遍。与便秘相比,腹泻中MS的患病率较高(OR = 1.27,95%CI 0.97至1.67)且与BMI无关。

结论
本项研究发现表明腹泻与NAFLD之间的关联独立于BMI。

原始出处:

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    2020-03-25 gaoxiaoe
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  5. 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    2020-07-18 feather89
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  8. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438545, encodeId=65461438545b8, content=<a href='/topic/show?id=85f7536e57f' target=_blank style='color:#2F92EE;'>#慢性腹泻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53675, encryptionId=85f7536e57f, topicName=慢性腹泻)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Dec 02 14:36:00 CST 2019, time=2019-12-02, status=1, ipAttribution=)]
    2019-12-23 许安
  9. 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肠易激综合征(IBS)在参加海湾战争(GW)的退伍军人中发生率高达33%。其中的机制可能为肠道微生物菌群(包括小肠细菌过度生长(SIBO))的改变在IBS的发展中起作用。利福昔明是一种不易被机体吸收的抗生素,也许可以通过恢复正常的肠道微生物群来改善IBS症状。这项研究的目的是比较利福昔明与安慰剂对没有便秘的IBS退伍军人的IBS症状和生活质量(QOL)的改善情况。

Gastroenterology:长期增加膳食纤维的摄入能降低老年妇女大便失禁的风险

目前,临床工作中医生经常把纤维补充剂用于治疗大便失禁(FI)的治疗中,但对膳食纤维在预防FI中的作用知之甚少。本项研究试图阐明膳食纤维在预防老年妇女大便失禁中的作用。

J Gastroenterology:质子泵抑制剂使用对艰难梭菌感染风险的影响

虽然有几项关于质子泵抑制剂(PPIs)使用与艰难梭菌感染(CDI)风险增加之间关联的研究,但缺乏详细研究分析PPI使用对CDI风险的影响。本研究调查了PPI的剂量,持续时间和类型与CDI风险之间的关系。

Clin Trans Gastro:水通道蛋白在腹泻肠易激综合征结肠黏膜活检中的表达分析

我们已知,水通道蛋白(AQP)通道参与调节结肠体液稳态,并且有文献报道,在人结肠上皮细胞中检测到几个AQP通道。在先前的研究中,喂食1%胆酸钠的大鼠其AQP3,7和8水平明显增加,表明AQP参与胆汁酸腹泻(BAD)。因此,本项研究的目的是比较肠易激综合征-腹泻(IBS-D)患者的直肠乙状结肠粘膜(RSM)活检中的AQP表达(分为正常或高粪便BA排泄的患者)和IBS-便秘患者(IBS-C) )与健康

J Gastroenterology:抑酸药会导致艰难梭菌感染风险增加

质子泵抑制剂(PPIs)的使用与艰难梭菌感染(CDI)风险增加之间研究虽然有一些,但缺乏详细研究分析PPI使用对CDI感染风险的影响。因此,本项研究旨在探究PPI的剂量,持续时间和类型与CDI感染风险之间的关系。