J Gastroen Hepatol:口服烟草提取物或吸烟对克罗恩病患者预后的影响

2017-12-31 zhangfan MedSci原创

研究发现,口服烟草提取物以及吸烟对克罗恩病患者疾病表现、药物治疗以及手术需求的影响无显著差异,任何形式的烟草使用都与随访期间的住院治疗风险有关

吸烟与克罗恩病(CD)的不良预后有关,但口服烟草提取物(OT)对克罗恩病人预后的影响尚不清楚。近日研究人员考察了吸烟、口服烟草提取物与CD预后的关系。

研究人员对2004-16年间CD患者的相关资料进行回顾分析,评估的参数包括基线疾病特征(位置、行为、发病年龄、肛周疾病、肠外表现),病程模式和结果(手术、住院治疗、免疫调节剂、生物制剂和类固醇的使用)。

总计426名患者参与研究,年龄39.9岁,男性占59.9%,平均随访71个月。40名患者有烟草提取物服用史,59人有吸烟史,烟草提取物或吸烟史患者每天使用至少2年以上。OT与男性和吸烟相关。OT或吸烟患者基线特征类型,但吸烟人群上消化道疾病率较低。OT或吸烟对手术、免疫调节或生物制剂无影响。日或累计的烟草暴露与患者结果和病程无关。正在吸烟(OR 2.59)或服用口服烟草(OR 2.97)的人群其住院风险增加。

研究发现,口服烟草提取物以及吸烟对克罗恩病患者疾病表现、药物治疗以及手术需求的影响无显著差异,任何形式的烟草使用都与随访期间的住院治疗风险有关。

原始出处:

Umang Arora et al. Effect of oral tobacco use and smoking on outcomes of Crohn's disease in India. J Gastroen Hepatol. 28 December 2017.

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    2018-06-03 许安
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  4. [GetPortalCommentsPageByObjectIdResponse(id=1691951, encodeId=07d1169195183, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f4729287700, createdName=bnurmamat, createdTime=Mon Sep 17 19:23:00 CST 2018, time=2018-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072026, encodeId=ce5720e202616, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sun Jun 03 14:23:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711323, encodeId=6bda1e113232d, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Dec 08 19:23:00 CST 2018, time=2018-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275926, encodeId=8e2d2e592653, content=还可以吸烟呀?, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151102/IMG563643881070C8786.jpg, createdBy=f4241660247, createdName=小树, createdTime=Sat Jan 06 08:21:25 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275331, encodeId=7e6b2e533147, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Thu Jan 04 10:03:01 CST 2018, time=2018-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310196, encodeId=c75a13101963f, content=<a href='/topic/show?id=53036e11185' target=_blank style='color:#2F92EE;'>#烟草#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67111, encryptionId=53036e11185, topicName=烟草)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a8d381, createdName=mnda, createdTime=Tue Jan 02 00:23:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426964, encodeId=f6981426964c0, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Tue Jan 02 00:23:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274136, encodeId=0c412e41361f, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun Dec 31 10:45:43 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274110, encodeId=36942e411064, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sun Dec 31 09:38:53 CST 2017, time=2017-12-31, status=1, ipAttribution=)]
    2018-01-06 小树

    还可以吸烟呀?

    0

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    2018-01-04 大爰

    学习了谢谢分享!!

    0

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    2018-01-02 mnda
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    2018-01-02 gwc384
  8. [GetPortalCommentsPageByObjectIdResponse(id=1691951, encodeId=07d1169195183, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f4729287700, createdName=bnurmamat, createdTime=Mon Sep 17 19:23:00 CST 2018, time=2018-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072026, encodeId=ce5720e202616, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sun Jun 03 14:23:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711323, encodeId=6bda1e113232d, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Dec 08 19:23:00 CST 2018, time=2018-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275926, encodeId=8e2d2e592653, content=还可以吸烟呀?, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151102/IMG563643881070C8786.jpg, createdBy=f4241660247, createdName=小树, createdTime=Sat Jan 06 08:21:25 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275331, encodeId=7e6b2e533147, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Thu Jan 04 10:03:01 CST 2018, time=2018-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310196, encodeId=c75a13101963f, content=<a href='/topic/show?id=53036e11185' target=_blank style='color:#2F92EE;'>#烟草#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67111, encryptionId=53036e11185, topicName=烟草)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a8d381, createdName=mnda, createdTime=Tue Jan 02 00:23:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426964, encodeId=f6981426964c0, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Tue Jan 02 00:23:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274136, encodeId=0c412e41361f, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun Dec 31 10:45:43 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274110, encodeId=36942e411064, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sun Dec 31 09:38:53 CST 2017, time=2017-12-31, status=1, ipAttribution=)]
    2017-12-31 明月清辉

    谢谢分享.学习了

    0

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    2017-12-31 龙胆草

    学习谢谢分享

    0

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Aliment Pharmacol Ther:母乳喂养降低克罗恩病及溃疡性结肠炎风险?

包括克罗恩病(CD)和溃疡性结肠炎(UC)在内的炎性肠病(IBD)在全球范围内的发病率不断上升。 IBD的确切原因仍不完全清楚。通常认为IBD由遗传易感性、环境暴露和对益生菌肠道微生物群的免疫反应失调而引起。2017年11月,发表在《Aliment Pharmacol Ther》的一项由美国和澳大利亚科学家进行的系统评价和meta分析,考察了母乳喂养与CD和UC风险之间的相关性。

Sci Transl Med:揭秘维持肠道平衡的关键酶

肠道微生物组的不平衡,即“坏”的微生物多于“好”的被称为生态失调,这是由肠道炎症,抗生素或饮食等环境压力造成的。肠道生态失调可以加重克罗恩病和其他疾病,但这种关系背后的机制并没有被完全解释清楚,在这项研究中研究人员希望为患者提供更健康的细菌平衡。

Am J Gastroenterol:炎症性肠病治疗方案的辅助决策

生物疗法的用药决策是高度个体化的,人口统计学和疾病特征对治疗决策的影响十分有限,每一个炎症性肠病患者的特征均十分显著,难以进行统计分类