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ANN ONCOL：治疗前基因表达风险评分指导胃癌治疗

2018-01-22 MedSci MedSci原创

胃癌基因表达风险评分
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围手术期化疗是晚期胃癌成熟的治疗方式。治疗选择主要依据临床分析。ANN ONCOL近期发表了一篇文章，建立并验证了一项纳入临床和分子特征的预后评分系统，以期能改善这类患者的治疗决策。

围手术期化疗是晚期胃癌成熟的治疗方式。治疗选择主要依据临床分析。ANN ONCOL近期发表了一篇文章，建立并验证了一项纳入临床和分子特征的预后评分系统，以期能改善这类患者的治疗决策。

作者分析了626例胃癌和胃食管交界处肿瘤且接受的治疗措施包括原发切除和术前/围手术期治疗的患者。患者分为训练队列（n=269）和验证队列（n=357）。在切除的肿瘤中通过PCR检测11个目标基因的表达。建立并验证预测总生存的风险评分。通过10例患者的50处不同肿瘤区域分析瘤内异质性。风险评分包括CCL5、CTNNB1、EXOSC3和LATR1表达，临床分期，肿瘤位置和病理类型，两组不同评分的患者总生存情况显着不同。在独立队列和原发灶切除以及术前/围手术期治疗患者亚组中成功地验证了风险评分的作用。在肠型和非肠型肿瘤原发切除的患者中，高风险和低风险患者之间总生存有显着差异。

文章最后认为，该研究建立的风险评分可以对改善胃癌患者围手术期化疗的管理作出贡献。

原始出处：
L Baure,A Hapfelmeier,et al.A novel pretherapeutic gene expression-based risk score for treatment guidance in gastric cancer.ANN ONCOL.January 2018 doi:https://doi.org/10.1093/annonc/mdx685

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    2018-11-03 ms3892185887221420

    #胃癌治疗#

    0

  2. 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    2018-01-26 李东泽

    是很好的学习材料.不错.以后会多学习.

    0

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    2018-01-25 137****9095

    henhao

    0

  4. 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    2018-01-24 1e0e5a1fm42(暂无匿称)

    henhao

    0

  5. 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    2018-01-24 bioon1

    #基因表达#

    0

  6. 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2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281302, encodeId=a651281302f5, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=353a2047758, createdName=137****9095, createdTime=Tue Jan 23 19:30:34 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281062, encodeId=8af5281062c0, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=7dcf1938111, createdName=1e0e5a1fm42(暂无匿称), createdTime=Mon Jan 22 21:46:21 CST 2018, time=2018-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281041, encodeId=111828104113, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Mon Jan 22 19:58:46 CST 2018, time=2018-01-22, status=1, ipAttribution=)]
    2018-05-08 minlingfeng

    #Oncol#

    0

  7. 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    2018-01-23 137****9095

    henhao

    0

  8. 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    2018-01-23 137****9095

    henhao

    0

  9. 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    2018-01-22 1e0e5a1fm42(暂无匿称)

    henhao

    0

  10. 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    2018-01-22 131****1460

    学习了受益匪浅

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