J Indian Soc Periodontol:ω-3多不饱和脂肪酸膳食补充剂是否有助于慢性牙周炎的治疗

2018-03-08 MedSci MedSci原创

使用ω-3多不饱和脂肪酸(ω-3 PUFAs)进行的宿主调节通过替代和抑制花生四烯酸(AA)的代谢而具有抗炎和促分解作用。本研究旨在评估慢性牙周炎患者伴或不伴膳食补充ω-3多不饱和脂肪酸(PUFAs)后刮治和根面平整(SRP)后的临床参数和唾液白细胞介素-1β(IL-1β)的水平。 研究共纳入了40名重度慢性牙周炎的患者。测试组和对照组进行全口牙周检查及刮治和根面平整(每组20人)。 对照组单独接

使用ω-3多不饱和脂肪酸(ω-3 PUFAs)进行的宿主调节通过替代和抑制花生四烯酸(AA)的代谢而具有抗炎和促分解作用。本研究旨在评估慢性牙周炎患者伴或不伴膳食补充ω-3多不饱和脂肪酸(PUFAs)后刮治和根面平整(SRP)后的临床参数和唾液白细胞介素-1β(IL-1β)的水平。

研究共纳入了40名重度慢性牙周炎的患者。测试组和对照组进行全口牙周检查及刮治和根面平整(每组20人)。

对照组单独接受SRP,而试验组接受每日剂量为700mg的ω-3 PUFA胶囊3个月。在基线,1个月和3个月的持续时间检查所有临床参数,而在基线和治疗后3个月检查唾液中的IL-1β水平。

结果显示,所有临床结果的改善在3个月内都是相似的。除了出血指数改善和IL-1β水平降低外,临床参数的改善在组间比较上没有统计学差异,试验组与对照组相比具有统计学差异(P <0.05)。

该研究结果表明,尽管使用ω-3 PUFAs进行辅助治疗可以调节细胞因子水平并显示脯氨酸溶解特性,但其对临床结果的重要性可能是有争议的。因此,可用作慢性牙周炎的辅助治疗。

原始出处:

Umrania VV, Rao Deepika PC, Kulkarni M. Evaluation of dietary supplementation of omega-3 polyunsaturated fatty acids as an adjunct to scaling and root planing on salivary interleukin-1β levels in patients with chronic periodontitis: A clinico-immunological study. J Indian Soc Periodontol. 2017 Sep-Oct;21(5):386-390. doi: 10.4103/jisp.jisp_16_16.

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style='color:#2F92EE;'>#膳食补充剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85928, encryptionId=89268592854, topicName=膳食补充剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e5ef29855394, createdName=zsyan, createdTime=Tue May 29 17:44:00 CST 2018, time=2018-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1932134, encodeId=97471932134a7, content=<a href='/topic/show?id=286810126909' target=_blank style='color:#2F92EE;'>#饱和脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101269, encryptionId=286810126909, topicName=饱和脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b96f328, createdName=wwzzly, createdTime=Thu Jan 24 03:44:00 CST 2019, time=2019-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350363, encodeId=09ce1350363ba, content=<a href='/topic/show?id=224a85904ad' target=_blank style='color:#2F92EE;'>#膳食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85904, encryptionId=224a85904ad, topicName=膳食)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Mar 10 04:44:00 CST 2018, time=2018-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368655, encodeId=169d13686555c, content=<a href='/topic/show?id=0e30535657b' target=_blank style='color:#2F92EE;'>#慢性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53565, encryptionId=0e30535657b, topicName=慢性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c64275, createdName=piaojinhua, createdTime=Sat Mar 10 04:44:00 CST 2018, time=2018-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378713, encodeId=2dd713e871397, content=<a href='/topic/show?id=d27b430265e' target=_blank style='color:#2F92EE;'>#多不饱和脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43026, encryptionId=d27b430265e, topicName=多不饱和脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=284b425, createdName=zll0625, createdTime=Sat Mar 10 04:44:00 CST 2018, time=2018-03-10, status=1, ipAttribution=)]
    2018-11-29 feather89
  5. 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  6. 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  7. 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  8. 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createdName=piaojinhua, createdTime=Sat Mar 10 04:44:00 CST 2018, time=2018-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378713, encodeId=2dd713e871397, content=<a href='/topic/show?id=d27b430265e' target=_blank style='color:#2F92EE;'>#多不饱和脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43026, encryptionId=d27b430265e, topicName=多不饱和脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=284b425, createdName=zll0625, createdTime=Sat Mar 10 04:44:00 CST 2018, time=2018-03-10, status=1, ipAttribution=)]
    2018-03-10 zhaojie88
  9. 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