JAHA:经导管二尖瓣修复后左心房功能的预后影响

2019-05-05 xiangting MedSci原创

目前的分析表明在接受MitraClip植入的患者中,LA功能的变化与包括残余二尖瓣反流、跨瓣梯度升高和左心室功能在内的重要指标相关。

左心房(LA)功能能够预测各种血管疾病的临床结局。然而,在二尖瓣反流情况下的数据有限。这项研究目的是评估患者使用MitraClip进行经导管二尖瓣修复术后LA射血分数(LAEF)的潜在变化及其预后价值。

纳入88名接受MitraClip植入的连续性患者,这些患者在基线时进行了完整的超声心动图检查,并在术后3至6个月进行了随访。 58%的患者LAEF有所改善。LAEF的变化与残余二尖瓣反流、残余跨瓣梯度和左心室射血分数的变化相关。与对照相比,残余二尖瓣反流≥2级的患者(LAEF的变化,-6%[四分位数[IQR],-9-1%] vs 4%[IQR,-5-15%];P=0.05)和残余跨瓣梯度≥5mmHg的患者(LAEF的变化,-2%[IQR,-9-9%] vs 5%[IQR,-4-16%];P=0.03)显示LAEF下降。此外,LAEF与左心室射血分数的变化显著相关(r=0.40;P=0.001)。关于临床结局,LAEF恶化的患者在随访中由纽约心脏病协会分级评估的心衰症状更严重。最后,LAEF的变化被确定为全因死亡率的独立预测因子(风险比,0.94;95%CI,0.90-0.98 [P=0.008])。

目前的分析表明在接受MitraClip植入的患者中,LA功能的变化与包括残余二尖瓣反流、跨瓣梯度升高和左心室功能在内的重要指标相关。重要的是,LA 功能的改变是全因死亡率的强预测因子。

原始出处:

Jakob Ledwoch. Prognostic Impact of Left Atrial Function Following Transcatheter Mitral Valve Repair. JAHA. 04 May 2019.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

 


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    2019-09-22 ylz8411
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    2019-05-07 zhaohui6731
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    2019-05-07 wwzzly
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    2019-05-07 lsj631
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    2019-05-07 sodoo

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