PLoS One:房颤患者心源性猝死的预测指标

2017-11-14 xiangting MedSci原创

在ARIC研究中,与非突发性CV死亡无关的SCD预测因子包括BMI增加,心率增加和低白蛋白。

之前有研究称在一般人群中房颤(AF)与心源性猝死(SCD)的风险升高相关。这项研究的目标是确定社区动脉粥样硬化风险(ARIC)研究,一项以社区为基础的队列研究,中的房颤患者SCD的预测因子。

纳入所有参加第1次访问(1987-89),之前没有AF的患者(n = 14,836)。通过心电图和出院代码确定了2012年前的偶发性AF。SCD是由医师判定的。使用原因特异性Cox比例风险模型,然后逐步选择(向后消除,移除所有p>0.10的变量),以确定房颤患者SCD的预测因子。

2321名(15.6%)参与者(45-64岁,58%男性,18%黑人)出现AF。在平均3.3年中,房颤患者中有110例(4.7%)发生SCD。房颤患者SCD的预测因子包括高龄,体重指数(BMI),冠心病,高血压糖尿病,目前吸烟,左心室肥厚,心率增加和白蛋白下降。预测因子只与SCD有关,而不与其他心血管(CV)死亡相关,包括BMI增加(HR每增加5个单位,1.15,95%CI,0.97-1.36,p = 0.10),心率增加(HR每增加SD,1.18, 95%CI 0.99-1.41,p = 0.07)和低白蛋白(HR每下降1SD 1.23,95%CI 1.02-1.48,p = 0.03)。

在ARIC研究中,与非突发性CV死亡无关的SCD预测因子包括BMI增加,心率增加和低白蛋白。下一步需要更大的社区队列研究来证实这些发现,并阐明基本机制以利于预防SCD的发生。

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    2017-11-16 mhm295
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    2017-11-14 1ddf0692m34(暂无匿称)

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