Lancet Neurol:癫痫发作的周期节律研究

2018-09-14 zhangfan MedSci原创

研究认为癫痫发作周期的确存在节律性,但不同患者的发作周期存在差异,对患者进行发作周期跟踪指导癫痫临床治疗的关键参数

长期以来,研究人员一直怀疑癫痫发作存在周期节律性,癫痫的发作率在数周、几个月甚至几年内周期性地上升和下降。近日研究人员就癫痫患者在多个时间尺度上发作周期的强度和流行率进行了考察。

研究人员对2个队列的顽固性局灶性癫痫患者的研究数据进行考察(SeizureTracker和NeuroVista研究)。NeuroVista研究包含12名参与者,SeizureTracker研究包含1118名参与者,其中SeizureTracker队列中891 人(80%)以及NeuroVista队列中11人(92%)显示出昼夜节律(24小时)调节性癫痫发作。NeuroVista队列中,患者8在前1周存在显著的发作周期,而患者1和7也存在相近的1周发作周期,患者2的发作周期为2周。SeizureTracker队列中,1118名患者中有多达233人显示出明显的1周发作周期, 多达247人出现显著的3周以上发作周期。性别对周期差异的影响不显著,发作高峰期间患者一周中的每一天均会发作。

研究认为癫痫发作周期的确存在节律性,但不同患者的发作周期存在差异,对患者进行发作周期跟踪指导癫痫临床治疗的关键参数。

原始出处:

Philippa J Karoly et al. Circadian and circaseptan rhythms in human epilepsy: a retrospective cohort study. Lancet Neurol. September 12 2018.

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    2019-04-29 yinhl1978
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    2019-01-01 howi
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    2018-09-18 12282355m97暂无昵称

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    2018-09-17 12282355m97暂无昵称

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