Asian Pac J Allergy Immunol:患有或不患有过敏性鼻炎的哮喘儿童中,Th17细胞调控的免疫应答比较

2018-04-07 AlexYang MedSci原创

最近,有研究人员在患有或者不患有过敏性鼻炎的哮喘儿童中,调查了Th17细胞调控的免疫应答是否具有差异。研究人员在儿童中进行了一个案例-对照比较试验,其中包括67名哮喘(AS)儿童,50儿童患有过敏性鼻炎,52名儿童同时患有AS和AR(ASR),25名为传染性鼻炎(IR)和55名健康对照(HC)。研究人员使用的技术包括流式细胞仪、酶联免疫吸附试验等。研究发现,组内比较阐释了Th17细胞在ASR组中水

最近,有研究人员在患有或者不患有过敏性鼻炎的哮喘儿童中,调查了Th17细胞调控的免疫应答是否具有差异。研究人员在儿童中进行了一个案例-对照比较试验,其中包括67名哮喘(AS)儿童,50儿童患有过敏性鼻炎,52名儿童同时患有AS和AR(ASR),25名为传染性鼻炎(IR)和55名健康对照(HC)。研究人员使用的技术包括流式细胞仪、酶联免疫吸附试验等。

研究发现,组内比较阐释了Th17细胞在ASR组中水平最高((0.89% ± 0.27) %),其次分别为AS组((0.82 ± 0.29) %)和AR组((0.78 ± 0.17) %)(P<0.05)。在屋尘螨(HDM)抗原体外刺激后,IL-4和IL-17E在来自过敏性儿童(AS组、AR组和ASR组)PBMCs的培养基上清液中的水平显著增加。另外,IL-17E处理的来源自过敏性儿童(AS组、AR组和ASR组)的Th细胞,Th2细胞因子的释放被显著诱导,而在IR组和HC组中没有相似的结果。

最后,研究指出,他们的研究结果初步阐释了Th17细胞和它的相关细胞因子也许参与了气道炎症疾病发病机理中,并且在患有过敏性鼻炎和不患有过敏性鼻炎哮喘儿童中表现出了不同的免疫特性。

原始出处:

Qing M, Yongge L, Wei X et al. Comparison of Th17 cells mediated immunological response among asthmatic children with or without allergic rhinitis. Asian Pac J Allergy Immunol. 31 Mar 2018.

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    2018-08-06 luwei00
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    2018-04-09 膀胱癌
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    2018-04-09 zhaojie88
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    2018-04-07 戒馋,懒,贪

    谢谢分享学习了

    0

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Ther Clin Risk Manag:城市过敏性鼻炎儿童的变化的气源性致敏原谱回顾性研究

最近,有研究人员调查了过去10年的中国广州患有过敏性鼻炎(AR)儿童中,气源性过敏原谱和趋势的变化情况。研究是一个回顾性的研究,包括了4111名鼻高反应的儿童。研究人员对他们进行了血清特异性免疫球蛋白E测量,并在3328名患者中检测到了阳性结果,即为AR。另外,研究人员还对不同气源性致敏的阳性率和趋势进行了评估。研究发现,在AR儿童中,常见的气源性过敏原屋尘螨(HDMs)、猫狗皮屑、蟑螂、霉菌混合

Int Arch Allergy Immunol:成年人过敏性鼻炎中,白藜芦醇初级临床效果评估

白藜芦醇是一种天然的、非黄酮类多酚物质,具有抗炎症活性。之前有报道指出,白藜芦醇与羧甲基-β-葡聚糖一起使用能够在儿童过敏性鼻炎(AR)中减少鼻部症状。最近,有研究人员调查了白藜芦醇在患有AR的成年人中的治疗效果。研究人员进行了一个安慰剂对照、双盲研究。研究包括了151名(年龄18-60岁)患有重度永久性AR的成年人,并将他们分成安慰剂处理组(n=50)和布地奈德处理组(n=50)以及一个白藜芦醇

Am J Otolaryngol:鼻中隔成形术后,过敏性鼻炎对鼻塞治疗结果的影响

为了评估是否过敏性鼻炎(AR)的诊断会对开放式鼻中隔成形术(OSR)的外科手术治疗产生影响以及调查是否OSR是否能够对过敏性鼻炎患者或者不患有过敏性鼻炎的患者提供同样水平的生活质量的提高。研究人员在2008年到2015年进行了相关的回顾性研究,研究包括了646名经历了开放式鼻中隔成形术的病人。研究人员对满足入选条件的307名患者利用鼻塞症状评估(NOSE)模块进行了术前和术后生活质量(QoL)的测

Allergy:过敏性鼻炎患者舌下免疫治疗后,Th2细胞特异性减少

尽管Th2细胞在过敏性疾病,如过敏性鼻炎(AR)中具有很重要的角色,但是能够诱导和维持AR发病机理的因素仍旧不清楚。最近的舌下免疫治疗(SLIT)的发展有希望能够对AR的发病机理进行阐释。然而,哪一类Th2细胞亚群在屋尘螨诱导的AR(HDM-AR)中具有重要作用,SLIT对Th2细胞病理学影响以及Th2细胞亚群与SLIT效果之间的联系还没有明确的解释。最近,有研究人员在89名HDM-AR病人(43