Cancer Res：科学家发现肿瘤释放杀手肽，竟能将耐药癌细胞同伙“一网打尽”

2017-08-08 佚名来宝网

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在肯塔基大学的一项新研究中，癌症中心研究人员表明，对疗法敏感的癌细胞死亡死亡之后，他们释放一个“杀手级肽”，，可以将抵抗治疗的癌细胞一网打尽。

在肯塔基大学的一项新研究中，癌症中心研究人员表明，对疗法敏感的癌细胞死亡死亡之后，他们释放一个“杀手级肽”，，可以将抵抗治疗的癌细胞一网打尽。

癌症治疗后复发是一个常见的问题，也是导致癌症死亡的最大原因，这是因为初级肿瘤细胞通常包含抵抗治疗的癌细胞，这些癌细胞继续扩散，导致癌症的最终复发。

新的研究发表于《癌症研究》中，在研究报告中，科学家发现对疗法敏感的癌细胞会释放出一种名为PAF的片段肽。PAF可以使抵抗治疗的癌细胞灭亡，还能有效抑制转移性肿瘤的生长，此外，PAF只会进入到癌细胞中，对健康的细胞没有任何作用。

研究结果表明，这种自然产生的物质可以用来目标相邻或遥远癌症细胞，解决肿瘤转移和治疗抵抗的问题。

来自肯塔基大学与英国大学医学院的研究人员们在报道中指出：“在针对小鼠的试验中，我们发现PAF可以成功进入癌细胞内部，把抵抗治疗的癌细胞一网打尽的同时，又不会伤害小鼠健康的细胞。这一新的研究对医生如何计划他们的治疗起到了至关重要的作用，如何使用对疗法敏感肿瘤细胞释放的肽，来帮助消除耐药细胞。目前，我们正在发展可用于堵截抵抗治疗癌细胞转移的方法。”

原始出处：
Nikhil Hebbar, Ravshan Burikhanov, Nidhi Shukla, et al.A Naturally Generated Decoy of the Prostate Apoptosis Response-4 Protein Overcomes Therapy Resistance in Tumors.Cancer Res. 2017 Aug 1;77(15):4039-4050. doi: 10.1158/0008-5472.CAN-16-1970. Epub 2017 Jun 16.

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2018-03-01 旅苦化文_208

#科学家发现#

39 0
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2017-08-10 yxch36

#癌细胞#

0 0
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2017-08-09 luominglian113

学习了，谢谢分享。PAF片段

48 0
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2017-08-08 虈亣靌

学习了新知识

46 0
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2017-08-08 doctorJiangchao

谢谢分享。

48 0
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2017-08-08 随梦飞扬

这种自然产生的物质可以用来目标相邻或遥远癌症细胞，解决肿瘤转移和治疗抵抗的问题

46 0
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2017-08-08 1e10c84am36(暂无匿称)

文章很好，拜读了

45 0

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