Pediatrics：非心脏的先天性畸形新生儿的神经发育延迟比例达23%

2016-01-15 Seven L 译 MedSci原创

对新生儿进行非心脏先天性畸形（NCCA）是否会增加患儿神经系统发育延迟的风险？而NCCA新生儿术后神经发育延迟的发生率是多少？潜在危险因素又是什么？带着以上问题，研究者检索了 PubMed、 Embase和the Cochrane Library等数据库，收集涉及标准化认知或运动技能测试的原始文献。最终有23篇文章纳入了系统回顾和荟萃分析，涉及895名小儿。研究者使用了511名小儿的数据进行荟萃分

对新生儿进行非心脏先天性畸形（NCCA）是否会增加患儿神经系统发育延迟的风险？而NCCA新生儿术后神经发育延迟的发生率是多少？潜在危险因素又是什么？带着以上问题，研究者检索了 PubMed、 Embase和the Cochrane Library等数据库，收集涉及标准化认知或运动技能测试的原始文献。

最终有23篇文章纳入了系统回顾和荟萃分析，涉及895名小儿。研究者使用了511名小儿的数据进行荟萃分析。使用贝利婴儿发展量表在小儿12个月和24个月时进行评估。研究数据显示，认知发育延迟的中位数比例是23%（范围 3%-56%）。荟萃分析结果显示，认知评分低于普通人群平均值的0.5 SD（智力发育指数 MDI 92 ± 13，P < .001）。运动发育延迟的中位数比例是25%(范围 0%-77%)。荟萃分析结果显示，运动发育评分低于普通人群平均值的0.6 SD（精神运动发育指数 91 ± 14; P < .001）。纳入的文章中有一些报道了精神运动发育延迟的危险因素，如低出生体重儿、先天性畸形数目多、住院时间长、重复手术等。研究者也指出了，纳入的研究样本量均小，先天畸形也多种多样，不同研究选择的神经发育评估工具也不同等是荟萃分析的限制。

研究结果表明，新生儿NCCA术后认知和运动发育延迟的比例占了约23%，荟萃分析显示了神经发育结局与健康人群的常规分数低了0.5 SD。

原始出处：

Stolwijk LJ, Lemmers PM,et al.Neurodevelopmental Outcomes After Neonatal Surgery for Major Noncardiac Anomalies.Pediatrics. 2016 Jan 12.

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2016-06-20 sjzlzc007

#非心脏#

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2016-01-28 feather89

#PE#

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2016-07-16 hbwxf

#Pediatric#

19 0
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2016-05-24 ms9608593228839890

#DIA#

21 0
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2016-01-24 1de3b290m83(暂无匿称)

大系统

70 0
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2016-01-17 12499e01m47暂无昵称

#神经发育#

22 0
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2016-01-17 neurowu

#发育#

18 0
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2016-01-17 wushaoling

#畸形#

18 0
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2016-01-17 huirong

#先天性#

19 0

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Pediatrics：非心脏的先天性畸形新生儿的神经发育延迟比例达23%

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