J Virol:科学家发现甲型流感病毒M2蛋白顶端靶点在病毒复制中具有重要作用

2018-11-13 Etrgh 病毒学界

甲型流感病毒(IAV)M2蛋白是一种多功能的蛋白,在病毒的侵入、组装及释放方面起到重要的作用。近日,来自美国的科学家发现,M2蛋白顶端在IAV的有效复制过程中起到了重要的作用。该研究成果目前已发表至《Journal of Virology》杂志,题为“Influenza A Virus M2 Protein Apical Targeting Is Required for Efficient Vi

甲型流感病毒(IAV)M2蛋白是一种多功能的蛋白,在病毒的侵入、组装及释放方面起到重要的作用。近日,来自美国的科学家发现,M2蛋白顶端在IAV的有效复制过程中起到了重要的作用。该研究成果目前已发表至《Journal of Virology》杂志,题为“Influenza A Virus M2 Protein Apical Targeting Is Required for Efficient Virus Replication”。

为了研究M2蛋白顶端靶点在IAV复制过程中的作用,研究人员将IAV的M2蛋白顶端氨基酸序列分别进行了突变:1)引进C-terminal KKXX motif 内质网(ER)滞留信号;2)添加C-terminal AAASLLAP基地外侧质膜(Baso)靶向序列。



研究成果发现,M2蛋白改造后的IAV的病毒复制能力相对于野毒株显着下降,证实M2蛋白顶端在IAV复制过程中起到重要作用,且其M2蛋白顶端靶向ER的作用最强。

原始出处:Wohlgemuth N, Lane AP, Pekosz A. Influenza A Virus M2 Protein Apical Targeting Is Required for Efficient Virus Replication. J Virol. 2018 Oct 29;92(22). 

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    2018-11-24 随缘星空

    学习了

    0

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