SCI REP:阻塞性睡眠呼吸暂停与哮喘的关系分析!

2017-06-22 xing.T MedSci原创

这项研究表明哮喘患者阻塞性睡眠呼吸暂停的患病率相当高,甚至高于阻塞性睡眠呼吸暂停风险和SDB的患病率,对伴有阻塞性睡眠呼吸暂停/阻塞性睡眠呼吸暂停风险/SDB的哮喘患者应进行睡眠研究。

近日,Scientific reports 杂志上发表了一篇荟萃分析文章,该研究旨在评估阻塞性睡眠呼吸暂停(OSA)与哮喘之间存在的关系。

研究人员通过对几个电子数据库进行检索,确定了相关文献;并且采用随机效应荟萃分析得到了哮喘患者汇总估计的阻塞性睡眠呼吸暂停患病率、阻塞性睡眠呼吸暂停风险以及睡眠呼吸紊乱(SDB),同时,还获得了哮喘患者和非哮喘患者之间发病率合并的比值比。

在成年哮喘患者中,研究人员发现阻塞性睡眠呼吸暂停、阻塞性睡眠呼吸暂停的风险以及SDB的患病率(95%可信区间)分别为49.50[36.39-62.60] %、27.50[19.31-35.69] %和19.65[14.84-24.46]%。相比于没有哮喘的患者,哮喘患者患有阻塞性睡眠呼吸暂停、阻塞性睡眠呼吸暂停风险和SDB的几率分别要高出2.64[1.76-3.52]、3.73[2.90-4.57]和1.73[1.11-2.36]倍(所有P<0.00001)。与没有阻塞性睡眠呼吸暂停的哮喘患者相比,患有阻塞性睡眠呼吸暂停的成年哮喘患者体重指数显著升高。

这项研究表明哮喘患者阻塞性睡眠呼吸暂停的患病率相当高,甚至高于阻塞性睡眠呼吸暂停风险和SDB的患病率,对伴有阻塞性睡眠呼吸暂停/阻塞性睡眠呼吸暂停风险/SDB的哮喘患者应进行睡眠研究。

原始出处:

De-Lei Kong,et al. Association of Obstructive Sleep Apnea with Asthma: A Meta-Analysis.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-04446-6

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    2017-09-03 tomyang96
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    2017-06-26 杨利洪

    学习了分享了

    0

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    2017-06-23 微笑人参

    谢谢!学习了,

    0

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    2017-06-22 有备才能无患

    这项研究表明哮喘患者阻塞性睡眠呼吸暂停的患病率相当高,甚至高于阻塞性睡眠呼吸暂停风险和SDB的患病率,对伴有阻塞性睡眠呼吸暂停/阻塞性睡眠呼吸暂停风险/SDB的哮喘患者应进行睡眠研究。

    0

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    2017-06-22 胖红

    学习了很多的事情,

    0

相关资讯

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由此可见,在IPF患者中发生中度至重度OSA的患病率较高,而且重度OSA与CVD的存在密切相关,尤其是缺血性心脏病。

Am J Resp Crit Care:2型糖尿病患者的阻塞性睡眠呼吸暂停与视网膜病变!

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JCEM:阻塞性睡眠呼吸暂停动态增加夜间血浆游离脂肪酸、葡萄糖和皮质醇水平!

由此可见,CPAP撤退期间OSA复发会增加睡眠期间的FFA和葡萄糖,这与交感神经和肾上腺皮质活化有关。反复暴露于这些代谢变化可能会导致糖尿病和心血管疾病。

CHEST:减肥对OSA的影响

肥胖和阻塞性睡眠呼吸暂停(OSA)之间的相互作用是复杂的。虽然通常认为肥胖是OSA的主要原因,并且治疗OSA可以减轻体重的进一步增加,但是新的证据表明这两者之间的关系可能并不如此。肥胖解释了OSA关于呼吸暂停低通气指数定义的60%的不均一性,主要是<50岁的患者,在老年人中更少。此外,OSA患者使用持续气道正压通气的长期治疗与体重增加有关。这种体重增加效应可能是由于消除与OSA相关的呼吸功增

Eur Respir J:阻塞性睡眠呼吸暂停不是住院抑郁症发生的危险因素!

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Chest:COPD-OSA重叠综合征

慢性阻塞性肺疾病(COPD)和阻塞性睡眠呼吸暂停综合征(OSA)是常见的两种疾病,这也意味着,基于机会联合,这两种疾病合并发生(重叠综合征)可能也是常见的。然而,COPD不同的临床表型影响着共存的OSA的可能性,因为与肺气肿表型相关一些因素,如增加的肺容积和低体重指数(BMI)对OSA的发生具有一定的预防作用,而与慢性支气管炎表型相关的外周水肿和BMI的增加又可以促进OSA的发生。COPD和OSA