Semin Arthritis Rheu:颈动脉斑块可以预测类风湿性关节炎患者的心血管事件

2020-05-11 xiangitng MedSci原创

存在颈动脉斑块可以预测RA患者的CV事件和死亡。在RA患者中颈动脉斑块和QRISK3的预测能力高于mSCORE。

这项研究旨在探讨一个前瞻性定义并基于人群的类风湿性关节炎(RA)初始队列中,系统性冠脉风险评估(SCORE)和QRISK3算法以及颈动脉超声是否可以预测心血管(CV)事件和死亡。

2012年至2013年间,通过颈动脉超声对327例无糖尿病、慢性肾脏病或CV事件病史的连续性RA患者进行了研究。当时,根据改良的EULAR RA系统性冠心病风险评估(mSCORE)计算了CV风险。通过生存分析模型进行了为期五年的前瞻性随访研究。使用基线数据对基于2015/2016年更新的EULAR指南的EULAR mSCORE和QRISK3算法进行了回顾性检验。

随访1,984.25患者年后,23例患者死亡,27例出现CV事件。线性死亡率为1.16/100患者年(95%置信区间[CI]:0.74-1.73)。调整年龄、性别和病程后,使用颈动脉斑块的模型(危险比[HR]:6.10[95%CI:0.74-50.0];p=0.09)和另一个使用颈动脉斑块和QRISK3的模型(颈动脉斑块HR:6.12[95%CI:0.74-50.5];p=0.09和QRISK3每1%的HR:1.03[95%CI:0.99-1.07],p=0.11)是死亡的最佳预测指标,而使用颈动脉斑块的模型(HR:5.25[95%CI:1.41-19.50]; p=0.01)和另一个使用颈动脉斑块和QRISK3的模型(颈动脉斑块HR:5.13[95%CI:1.36-19.3]; p=0.02和QRISK3每1%的HR:1.03[95%CI:0.99-1.07],p=0.12)是CV事件的最佳预测指标。相比之下,mSCORE是死亡或CV事件风险的较弱预测指标。

存在颈动脉斑块可以预测RA患者的CV事件和死亡。在RA患者中颈动脉斑块和QRISK3的预测能力高于mSCORE。

原始出处:

Alfonso Corrales. Carotid plaques as predictors of cardiovascular events in patients with Rheumatoid Arthritis. Results from a 5-year-prospective follow-up study. Semin Arthritis Rheu. 08 May 2020.

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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Sat Jul 18 17:11:54 CST 2020, time=2020-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843581, encodeId=2f6a184358112, content=<a href='/topic/show?id=dab8100523bb' target=_blank style='color:#2F92EE;'>#颈动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100523, encryptionId=dab8100523bb, topicName=颈动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Sun Aug 02 13:11:54 CST 2020, time=2020-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266174, encodeId=6e0012661e4b4, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Wed May 13 05:11:54 CST 2020, time=2020-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280786, encodeId=5eaa1280e8626, content=<a href='/topic/show?id=c6ba1005490e' target=_blank style='color:#2F92EE;'>#颈动脉斑块#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100549, encryptionId=c6ba1005490e, topicName=颈动脉斑块)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7387164, createdName=zhangj7108, createdTime=Wed May 13 05:11:54 CST 2020, time=2020-05-13, status=1, ipAttribution=), 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attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Wed May 13 05:11:54 CST 2020, time=2020-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357499, encodeId=fa0b135e49962, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed May 13 05:11:54 CST 2020, time=2020-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483680, encodeId=f5491483680fe, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Wed May 13 05:11:54 CST 2020, time=2020-05-13, status=1, ipAttribution=)]
    2020-05-13 lmm397
  5. [GetPortalCommentsPageByObjectIdResponse(id=1643699, encodeId=fd97164369937, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Tue Oct 20 19:11:54 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972723, encodeId=5d0a19e2723d9, content=<a href='/topic/show?id=8a6a2e8839' target=_blank style='color:#2F92EE;'>#Arthritis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2788, encryptionId=8a6a2e8839, topicName=Arthritis)], attachment=null, authenticateStatus=null, 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  6. [GetPortalCommentsPageByObjectIdResponse(id=1643699, encodeId=fd97164369937, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Tue Oct 20 19:11:54 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972723, encodeId=5d0a19e2723d9, content=<a href='/topic/show?id=8a6a2e8839' target=_blank style='color:#2F92EE;'>#Arthritis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2788, encryptionId=8a6a2e8839, topicName=Arthritis)], attachment=null, authenticateStatus=null, 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  7. 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  8. 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    2020-05-13 zhaojie88
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