Gastroenterology:小肠克罗恩病伴狭窄的组织病理学评分系统

2019-09-03 MedSci MedSci原创

研究认为,目前缺乏有效的组织病理学评分系统来评估克罗恩病相关纤维肌肉狭窄,组织病理学指标的开发和验证是将来的研究重点

小肠狭窄是克罗恩病(CD)的常见并发症,目前尚无有效的药物治疗,且缺少有效的治疗效果评估手段,近日研究人员CD狭窄相关的组织学评分系统进行了系统回顾。

研究人员收集截至2019年3月13日的相关研究数据,使用组织学评分系统来表征小肠CD,并评估同一成年受试者的炎症和纤维化变化。

研究人员观察到评分系统之间存在显著的异质性,这些评分系统没有采用现代原则进行评价指数的开发,未接受有效性或可靠性测试。现有指标均未按公认的评价指标制定方法构建。缺乏关于其操作特性的基本知识。未提出评价肌成纤维细胞肥大或增生的重要病理成分的特异性指标。

研究认为,目前缺乏有效的组织病理学评分系统来评估克罗恩病相关纤维肌肉狭窄,组织病理学指标的开发和验证是将来的研究重点。

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    2019-09-04 许安
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    2019-09-05 jktdtl
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    2019-09-03 130****4638

    学习了,谢谢分享

    0

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