J Rheumatol:银屑病关节炎患者狼疮合并症的患病率高

2020-05-18 xiangting MedSci原创

与对照组相比,PsA患者中SLE的患病率升高了2.3倍。出现SLE的危险因素包括PsA诊断时的年龄大、PsA病程短和使用他汀类药物。

这项研究旨在评估银屑病关节炎(PsA)队列中狼疮(SLE)的患病率,并使用大型医疗服务提供者的数据库将其与普通人群进行比较。

研究分析了PsA队列的数据库(2002-2017),并根据年龄和性别与随机选择的对照进行匹配,分析人口学、临床和实验室表现以及使用的药物。统计分析根据情况采用了t检验、卡方检验。在PsA组中,将没有SLE的PsA患者作为对照,根据年龄和随访时间与伴SLE的PsA患者进行匹配,对发病率进行抽样。使用单因素和多因素条件logistic回归分析评估影响SLE进展的因素。

PsA组和对照组分别有4836名和24180名受试者,中位年龄为56±15岁,其中女性占53.8%。PsA组的18名患者(0.37%)和对照组的36名受试者(0.15%)被诊断为SLE(p=0.001)。没有PsA的SLE患者抗dsDNA和抗心磷脂抗体更高。PsA组已知有诱发SLE潜力药物的使用率高于对照组。在PsA患者中,诊断时年龄大、PsA病程短和使用他汀类药物与SLE相关。

与对照组相比,PsA患者中SLE的患病率升高了2.3倍。出现SLE的危险因素包括PsA诊断时的年龄大、PsA病程短和使用他汀类药物。PsA与SLE之间的关联可能会影响治疗选择和药物开发。

原始出处:

Danielle Korkus. Increased prevalence of Lupus Co-morbidity in Patients with Psoriatic Arthritis: A Population-Based Case-Controlled Study. J Rheumatol. 15 May 2020.

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    2020-05-20 lmm397
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