Nat Med:维生素B3或可治疗急性肾损伤?

2018-08-22 风铃 生物探索

8月20日,《Nature Medicine》期刊发表了这一篇题为“De novo NAD+ biosynthetic impairment in acute kidney injury in humans”文章,由Beth Israel Deaconess医学中心的肾病学家和首席研究员Samir M. Parikh领导的多学科研究小组最新证实,一种维生素B3有望预防急性肾损伤。



8月20日,《Nature Medicine》期刊发表了这一篇题为“De novo NAD+ biosynthetic impairment in acute kidney injury in humans”文章,由Beth Israel Deaconess医学中心的肾病学家和首席研究员Samir M. Parikh领导的多学科研究小组最新证实,一种维生素B3有望预防急性肾损伤。

急性肾损伤是一组临床综合征,是指突发和持续的肾功能突然下降。当身体处于极度压力状态时,容易引发这一病症。

Samir M. Parikh团队发现,在急性肾损伤病例中,维生素B3在摄入后代谢的最终结果——NAD+水平会下降。

“我们发现,重症监护室或者经历过一场大手术的高风险患者尿液中的NAD+水平明显下降。更重要是的,口服维生素B3能够上调这一指标。”Samir M. Parikh解释道,“虽然现在下结论还为时尚早,但是这项研究预示,未来我们或许可以通过非侵入性检测NAD+,甚至于可以通过提高NAD+水平来治疗急性肾损伤。”

动物试验

他们以患有急性肾损伤的小鼠为模型,发现其尿液中的quinolinate(NAD+生成过程中一种被忽视的中间体)含量很高。这意味着,负责将quinolinate转化为NAD+的QPRT酶活性受到抑制。随着QPRT酶的阻断,NAD+水平下降。

研究团队利用CRISPR基因编辑技术,构建了一个小鼠模型——抑制QPRT酶活性,但是没有肾损伤。结果显示,它们同样表现出类似于急性肾损伤的病理变化:NAD+水平下降、quinolinate水平增加、肾损伤风险增加。

临床研究

在临床研究中,研究小组发现,接受大手术的急性肾损伤高风险患者存在高水平的quinolinate。同时,在另一项对329名同样有急性肾损伤风险的重症监护病房患者的研究中,他们再一次证实这一代谢模式。随后,他们给41名心脏手术患者注射了大剂量的口服维生素B3。

“我们的结果表明,NAD+生物合成在人类急性肾损伤期间会受损,而增加维生素B3水平可能是一种安全有效的应对之策。更重要的是,我们发现,尿液检测数据可以反映肾脏损伤,并预测不良后果。” Samir M. Parikh总结道。 

原始出处;

Ali Poyan Mehr, Mei T. Tran, Kenneth M. Ralto, et,al. De novo NAD+ biosynthetic impairment in acute kidney injury in humans. Nature Medicine (2018)  20 August 2018

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    新知识

    0

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    2018-08-24 鹏远

    谢谢分享

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1883263, encodeId=708a188326316, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue Jan 22 14:39:00 CST 2019, time=2019-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1701408, encodeId=1c401e014089a, content=<a href='/topic/show?id=220ee90625a' target=_blank style='color:#2F92EE;'>#维生素B3#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79062, encryptionId=220ee90625a, topicName=维生素B3)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d94630353217, createdName=wleon8905, createdTime=Sun May 05 16:39:00 CST 2019, time=2019-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341351, encodeId=823134135178, content=新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9e3b2411969, createdName=1237a7a1m07暂无昵称, createdTime=Mon Aug 27 21:41:01 CST 2018, time=2018-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=340539, encodeId=e2a5340539c4, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f1ba2215278, createdName=鹏远, createdTime=Fri Aug 24 11:10:23 CST 2018, time=2018-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397609, encodeId=81ff139e60976, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Fri Aug 24 04:39:00 CST 2018, time=2018-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508536, encodeId=8e2d1508536a7, content=<a href='/topic/show?id=68b0e9055f7' target=_blank style='color:#2F92EE;'>#维生素B#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79055, encryptionId=68b0e9055f7, topicName=维生素B)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=17599981768, createdName=马龙, createdTime=Fri Aug 24 04:39:00 CST 2018, time=2018-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609078, encodeId=d8fa16090e874, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Aug 24 04:39:00 CST 2018, time=2018-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=340165, encodeId=0f2134016552, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed Aug 22 15:10:15 CST 2018, time=2018-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=340164, encodeId=b2e634016469, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed Aug 22 15:10:03 CST 2018, time=2018-08-22, status=1, ipAttribution=)]
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    2018-08-24 马龙
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    2018-08-22 清风拂面

    谢谢分享学习

    0

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    2018-08-22 清风拂面

    谢谢分享学习

    0

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