Clin Gastroenterology H: 低剂量阿司匹林使用者中上消化道出血的发生率

2019-04-07 不详 MedSci原创

目前对于低剂量阿司匹林使用者的观察性研究,特别是关于上消化道出血和下消化道出血(UGIB和LGIB)发生率的数据很少。本项研究的目的是估计英国低剂量阿司匹林的患者中UGIB和LGIB的发病率,并对住院状况和死亡率进行分析。

背景与目的
目前对于低剂量阿司匹林使用者的观察性研究,特别是关于上消化道出血和下消化道出血(UGIB和LGIB)发生率的数据很少。本项研究的目的是估计英国低剂量阿司匹林的患者中UGIB和LGIB的发病率,并对住院状况和死亡率进行分析。

方法
研究人员对英国健康改善网络初级保健数据库(2000-2012)中确定的199079名低剂量阿司匹林患者(中位年龄64.0岁)进行了一项基于人群的研究,以确定新的UGIB和LGIB病例。在多步验证后,研究人员计算了整体和年龄和性别特异性发病率。

结果
研究结果显示所有低剂量阿司匹林患者中有1115次UGIB和1936次LGIB事件; 大多数患有UGIB事件的受试者(58.9%)住院,而大多数患有LGIB事件的受试者被转诊至二级保健(72.8%)。对于患有UGIB(95%CI,0.91-1.02)和对于具有LGIB(95%CI,1.60-1.75),每1000人年的GIB的粗发病率为0.97。GIB住院患者每***年的发病率为0.57(95%CI,0.53-0.61),LGIB为0.45(95%CI,0.42-0.49)。致死性UGIB(95%CI,0.04-0.07),致命性LGIB为0.01(95%CI,0.01-0.02),非致命性UGIB为0.91(95%CI,0.86-0.97),每1000人年的发病率为0.06,非致命性LGIB为1.66(95%CI,1.59-1.74)。

结论
本项研究表明低剂量阿司匹林使用者中LGIB的发病率高于UGIB的发病率。然而,LGIB住院肠道出血的发生率和30天死亡率低于UGIB。

原始出处:

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    2019-09-19 许安
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  5. 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  6. 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  9. 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