JAMA Netw Open:“中国急性缺血性脑卒中降压研究”全新分析:高血压患者中风后尽早启动降压有获益

2019-08-07 朱柳媛 中国循环杂志

近年来,对于急性缺血性中风发作后降压治疗对临床预后的影响,大多数临床研究得出了中性的结果。

近年来,对于急性缺血性中风发作后降压治疗对临床预后的影响,大多数临床研究得出了中性的结果。

7月31日,苏州大学医学部公共卫生学院仲崇科等人在JAMA网络开放子刊上发表的CATIS(中国急性缺血性脑卒中降压研究)的一项次要分析结果提示,急性缺血性中风发作后,对于本来就有高血压的人来说,继续进行降压治疗可能有预防中风复发的作用,但对于既往没有高血压的人来说,应基于其临床情况来决定是否启动降压治疗。

总体上,急性缺血性中风发作后立即启动降压治疗与中风发作两周或出院时死亡和明显残疾(改良Rankin量表评分≥3分)的复合终点无关。

分析显示,在有高血压史的患者中,中风发作后尽早启动降压治疗者3个月中风复发和血管性事件发生风险分别降低了56%和34%。

而在无高血压史的患者中,降压治疗对3个月后中风复发(OR=3.43,95% CI:0.94~12.55,P=0.06)和血管性事件(OR=1.91,95% CI:0.75~4.83,P=0.17)发生风险无明显影响。

CATIS为一项多中心、单盲、盲终点的随机临床研究,于2009~2013年纳入4071例伴收缩压升高的急性缺血性中风患者,随机分入两组:降压治疗组,给药24小时内收缩压降低10%~25%,7天内血压<140/90 mmHg;对照组,停止应用降压药物。患者的平均年龄为62岁,男士占64%。

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    2020-03-24 feather89
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content=<a href='/topic/show?id=9d32981418b' target=_blank style='color:#2F92EE;'>#降压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98141, encryptionId=9d32981418b, topicName=降压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Fri Aug 09 13:45:00 CST 2019, time=2019-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448283, encodeId=b84a1448283ae, content=<a href='/topic/show?id=5a9c102681f2' target=_blank style='color:#2F92EE;'>#高血压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Fri Aug 09 13:45:00 CST 2019, time=2019-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026425, encodeId=cc281026425f9, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Thu Aug 08 01:45:00 CST 2019, time=2019-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045880, encodeId=2f0c1045880ae, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Thu Aug 08 01:45:00 CST 2019, time=2019-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370922, encodeId=a7eb3e09220c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/12/05/12a5266c80310ee47ca553700511f53c.jpg, createdBy=b5512215816, createdName=永远不放弃, createdTime=Thu Aug 08 00:49:58 CST 2019, time=2019-08-08, status=1, ipAttribution=)]
    2020-02-21 canlab
  5. 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objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/12/05/12a5266c80310ee47ca553700511f53c.jpg, createdBy=b5512215816, createdName=永远不放弃, createdTime=Thu Aug 08 00:49:58 CST 2019, time=2019-08-08, status=1, ipAttribution=)]
  6. 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  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026425, encodeId=cc281026425f9, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Thu Aug 08 01:45:00 CST 2019, time=2019-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045880, encodeId=2f0c1045880ae, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Thu Aug 08 01:45:00 CST 2019, time=2019-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370922, encodeId=a7eb3e09220c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/12/05/12a5266c80310ee47ca553700511f53c.jpg, createdBy=b5512215816, createdName=永远不放弃, createdTime=Thu Aug 08 00:49:58 CST 2019, time=2019-08-08, status=1, ipAttribution=)]
  8. 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objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/12/05/12a5266c80310ee47ca553700511f53c.jpg, createdBy=b5512215816, createdName=永远不放弃, createdTime=Thu Aug 08 00:49:58 CST 2019, time=2019-08-08, status=1, ipAttribution=)]
    2019-08-08 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026425, encodeId=cc281026425f9, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Thu Aug 08 01:45:00 CST 2019, time=2019-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045880, encodeId=2f0c1045880ae, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Thu Aug 08 01:45:00 CST 2019, time=2019-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370922, encodeId=a7eb3e09220c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/12/05/12a5266c80310ee47ca553700511f53c.jpg, createdBy=b5512215816, createdName=永远不放弃, createdTime=Thu Aug 08 00:49:58 CST 2019, time=2019-08-08, status=1, ipAttribution=)]
    2019-08-08 guging

    中风是俗称,应该称为缺血性卒中吧

    0

  10. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026425, encodeId=cc281026425f9, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Thu Aug 08 01:45:00 CST 2019, time=2019-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045880, encodeId=2f0c1045880ae, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Thu Aug 08 01:45:00 CST 2019, time=2019-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370922, encodeId=a7eb3e09220c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/12/05/12a5266c80310ee47ca553700511f53c.jpg, createdBy=b5512215816, createdName=永远不放弃, createdTime=Thu Aug 08 00:49:58 CST 2019, time=2019-08-08, status=1, ipAttribution=)]
    2019-08-08 永远不放弃

    学习

    0

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近日,中国科学院院士、复旦大学生物医学研究院院长葛均波院士团队在Natrue子刊发文指出了心血管病治疗的新思路:靶向作用于赖氨酸去乙酰化酶修饰。

β受体阻滞剂治疗高血压的临床应用建议

β受体阻滞剂是心血管疾病常用的治疗药物,用于治疗冠心病、心力衰竭、快速性心律失常、高血压等。近年来,其在高血压治疗中的应用受到质疑,新版欧美及我国高血压指南关于其的使用推荐也有所不同。通过梳理β受体阻滞剂的作用机制、药理特点、临床研究证据及国内外相关指南,经多次专家讨论完成此临床应用建议,旨在促进此类药物的合理使用。

高血压管控 韩国在亚洲排**!为啥?

近日,《柳叶刀》、《科学报告》等著名期刊同时刊发了多项针对世界多个国家高血压管控现状的的大规模研究。从这些研究里,我们可以看到一个令人意外的事实:韩国的高血压控制水平远超中国、日本,在全世界范围内都名列前茅。

J Am Heart Assoc:贫穷地区高血压达标率低,死亡和并发症风险高

根据美国心脏协会杂志上的最新研究,尽管采用了同样的标准化降压治疗方案,低收入地区的高血压的血压控制效果较差,预后也较差。

收缩压与舒张压可独立预测心血管结局!控压不能厚此薄彼

高血压诊断标准≥130/80 mm Hg或140/90 mm Hg,差异大吗?