Stroke:行血栓切除术的急性缺血性卒中女性预后更好

2019-08-20 国际循环编辑部 国际循环

缺血性卒中患者行血管内卒中血栓切除术后的结局是否与性别有关,目前尚无报道。近期发表于Stroke的一篇文章,确定了性别对急性缺血性卒中血管内血栓切除术后结局(包括终生残疾结局)的影响。

缺血性卒中患者行血管内卒中血栓切除术后的结局是否与性别有关,目前尚无报道。近期发表于Stroke的一篇文章,确定了性别对急性缺血性卒中血管内血栓切除术后结局(包括终生残疾结局)的影响。

研究分析SWIFT(Solitaire FR:血栓切除术)、STAR(Solitaire FR:血栓切除术用于急性血运重建)和SWIFT PRIME(Solitaire FR:血栓切除术作为主要血管内治疗)队列中采用Solitaire支架治疗的患者。运用序贯回归和逻辑回归分析研究血管内卒中血栓切除术后影响预后的已知因素,并探讨性别对这些因素与预后(包括年龄和再灌注时间)相关性的影响。血栓切除术后的最佳寿命被定义为伤残调整寿命年,并通过性别校正后的卒中后预期寿命预测残疾。

结果显示,在接受血管内卒中血栓切除术的389例患者中,55%为女性,美国国立卫生研究院卒中量表(NIHSS)中位数为17(四分位间距:8~28)。女性与男性在出现缺陷严重程度(NIHSS评分,17 vs. 17,P=0.21)、闭塞位置(69% vs.64% M1,P=0.62)、梗死程度(Alberta卒中项目早期CT评分8 vs. 8,P=0.24)、发病率、大量再灌注(脑梗死溶栓2b/3,87% vs. 83%,P=0.37)和起始再灌注时间(294 vs. 302 min,P=0.46)无显著差异。尽管女性年龄较大(69岁 vs. 64岁,P<0.001),心房颤动发生率较高(45% vs. 30%,P=0.002),但与男性相比,校正后90天的功能独立性相似(OR=1.0;95%CI:0.6~1.6)。在校正年龄和卒中严重程度后,女性血管内卒中血栓切除术后的最佳寿命(伤残调整寿命年)更长,分别为10.6岁和8.5岁(P<0.001)。



(图引自原文献)

研究结论,女性尽管年龄更大、心房颤动发生率更高,但与男性相比,女性介入治疗后的功能结局更好、最佳寿命更长。

原始出处:
Sunil A. Sheth, Songmi Lee, Steven J. Warach, et al. Sex Differences in Outcome After Endovascular Stroke Therapy for Acute Ischemic Stroke. STROKE. Aug 15, 2019.

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    2019-08-21 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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